摘要
目的分析醒脾养儿颗粒与孟鲁司特钠联合治疗小儿牛奶蛋白过敏的效果。方法94例牛奶蛋白过敏患儿,使用随机数字表法分为对照组与研究组,每组47例。对照组采用孟鲁司特钠咀嚼片治疗,研究组在对照组的基础上应用醒脾养儿颗粒治疗。比较两组患儿的临床疗效以及炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、免疫因子(CD8^(+)、CD4^(+))水平。结果在总有效率比较中,研究组95.74%高于对照组的80.85%(P<0.05)。治疗后,研究组IL-6、TNF-α水平分别为(7.65±2.03)、(6.28±1.50)pg/ml,较对照组的(15.20±3.05)、(13.23±2.45)pg/ml低(P<0.05)。治疗后,研^(+)^(+)究组CD4水平(48.68±5.50)%较对照组的(44.50±4.86)%高,CD8水平(25.05±2.02)%较对照组的(28.64±3.05)%低(P<0.05)。结论醒脾养儿颗粒与孟鲁司特钠联合治疗小儿牛奶蛋白过敏效果确切,可以有效抑制患儿的炎症反应,提高其免疫功能,适于临床应用。
Objective To analyze the effect of Xingpi Yanger Granule combined with montelukast sodium in treating cow's milk protein allergy in children.Methods 94 children with cow's milk protein allergy were divided into the control group and the study group according to a random number table,with 47 cases in each group.The control group was treated with montelukast sodium chewable tablets,and the study group was treated with Xingpi Yanger Granule on the basis of the control group.The clinical efficacy and the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and immune factors(CD8^(+),CD4^(+))were compared between the two groups.Results In the comparison of total effective rate,the study group(95.74%)was higher than the control group(80.85%)(P<0.05).After treatment,the levels of IL-6 and TNF-αin the study group were(7.65±2.03)and(6.28±1.50)pg/ml,which were lower than(15.20±3.05)and(13.23±2.45)pg/ml in the control group(P<0.05).^(+)After treatment,CD4 level of(48.68±5.50)%in the study group was higher than^(+)(44.50±4.86)%in the control group,and CD8 level of(25.05±2.02)%was lower than(28.64±3.05)%in the control group(P<0.05).Conclusion The combination of Xingpi Yanger granule and montelukast sodium is effective in the treatment of cow's milk protein allergy in children,which can effectively inhibit the inflammatory reaction of children,improve their immune function.It is suitable for clinical application.
作者
刘得平
LIU De-ping(Allergy Department,Jinan Third People's Hospital,Jinan 250132,China)
出处
《中国现代药物应用》
2024年第3期118-120,共3页
Chinese Journal of Modern Drug Application
关键词
醒脾养儿颗粒
孟鲁司特钠
牛奶蛋白过敏
小儿
Xingpi Yanger Granule
Montelukast sodium
Cow's milk protein allergy
Children
