摘要
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis(OA),an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA,particularly in younger individuals.Metabolic abnormalities,such as obesity and typeⅡdiabetes,are strongly linked to OA,and they affect both weightbearing and non-weight-bearing joints,thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight.This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk,including the impact of abnormal glucose and lipid metabolism,the potential pathogenesis and targeted therapeutic strategies.
基金
supported by the National Key Research and Development Program of China(2021YFB3800800)to L.T.and D.C
supported by the National Natural Science Foundation of China(NSFC)grants(82030067,82161160342 and 82250710174)to D.C.,grant 82360429 to Y.C and grant 82172397 to L.T
supported by National Science Foundation of Guangxi(2022JJA141126)
Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University
China Postdoctoral Science Foundation(2019M650235)
Key R&D Project of Qingxiu District,Nanning,Guangxi(2021003)to Y.C.
the Hong Kong RGC grant HKU-17101821 to W.W.L.and D.C.
SIAT Innovation Program for Excellent Young Researchers to K.L.
作者简介
Guizheng Wei,contributed equally;Ke Lu,contributed equally;Correspondence:Yan Chen(cy003@connect.hku.hk);Correspondence:Liping Tong(lp.tong@siat.ac.cn)。
