摘要
卵巢储备是指卵巢内原始卵泡数量和卵母细胞质量,代表女性生育力水平,卵巢储备的消耗是生育力下降的主要原因.在生理状态下,原始卵泡的周期性募集和卵母细胞质量降低导致卵巢储备逐年下降,并在绝经后耗竭.病理状态下,卵巢储备的过早耗竭导致排卵提前停止,雌激素缺乏,女性患骨质疏松症和心血管疾病的风险增加.因此,卵巢储备对于女性健康至关重要.随着女性生育年龄的推迟以及对自身生育力保护意识的增强,女性生育力保护的社会需求日益增加.因此,围绕卵巢储备讨论相关的生育力保护措施不可或缺.本文综述了卵巢储备的变化规律,卵巢储备下降引起的疾病,卵巢储备下降的分子机制和相关的生育力保护手段,旨在为女性生育力保护提供支持.
Ovarian reserve refers to the quantity of primordial follicles and the quality of oocytes residing in the ovary,indicating female fertility.The depletion of ovarian reserve is the primary cause of fertility decline.Under physiological conditions,the cyclical recruitment of primordial follicles and the decline in oocyte quality gradually decrease the ovarian reserve until menopause.Under pathological conditions,premature depletion of ovarian reserve leads to early cessation of ovulation,estrogen deficiency,and increased risk of osteoporosis and cardiovascular diseases.Therefore,the ovarian reserve is crucial for female health.As the average age of childbearing increases and awareness of fertility preservation grows,there is a growing social demand for protecting female fertility.Thus,discussing the methods of fertility preservation related to the ovarian reserve is vital.Here,we review the dynamics of ovarian reserve,the diseases caused by declining ovarian reserve,the mechanisms of ovarian reserve depletion,and the relevant fertility preservation methods.
作者
涂婉
郭致远
何北佳
王红梅
闫龙
TU Wan;GUO ZhiYuan;He BeiJia;WANG HongMei;YAN Long(State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2024年第1期161-172,共12页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2019YFA0110900,2022YFA1104100)资助。
关键词
卵巢储备
卵巢储备下降机制
女性生育力保护
干细胞治疗
ovarian reserve
mechanisms of ovarian reserve depletion
female fertility preservation
stem cell therapy
作者简介
同等贡献作者:涂婉;同等贡献作者:郭致远;联系人:闫龙,E-mail:yanlong@ioz.ac.cn。
