摘要
目的 观察对泛发性大疱性类天疱疮(BP)采用度普利尤单抗治疗的临床效果及安全性。方法 回顾性分析2021年11月至2022年11月东北国际医院皮肤科收治的泛发性BP患者的临床资料。结果 10例中,男、女各5例,年龄44~91(73.5±13.6)岁,病程7~240(95.2±85.2)d。基础疾病包括糖尿病4例、冠心病4例、心功能不全1例、高血压7例、脑出血1例、脑梗死2例及直肠癌1例。结合典型临床表现、组织病理学和直接/间接免疫荧光检查,临床诊断为泛发性BP。患者均皮下注射度普利尤单抗治疗,首次600 mg,以后每2周注射1次300 mg。并根据临床表现,逐渐减量停用传统治疗药物。所有患者BP疾病面积指数(BPDAI)评分、皮损面积(BSA)及瘙痒数字评定量表(NRS)评分均降至0,随访6~12个月,未见复发。结论 度普利尤单抗治疗合并多种系统病变的泛发性BP疗效显著,安全性较好。
Objective To observe the clinical effect and safety of dupilumab in the treatment of generalized bullous pemphigoid(BP).Methods The clinical data of patients with generalized BP admitted to the Department of Dermatology of Northeast International Hospital from November 2021 to November 2022 were retrospectively analyzed.Results Among the 10 cases,5 were male and 5 were female,aged 44-91(73.5±12.8)years,the course of disease was 7-240(95.2±85.2)days.The underlying diseases included diabetes mellitus(4 cases),coronary heart disease(4 cases),cardiac insufficiency(1 case),hypertension(7 cases),cerebral hemorrhage(1 case),cerebral infarction(2 cases)and rectal cancer(1 case).Combined with typical clinical manifestations,histopathology,and direct/indirect immunofluorescence,the clinical diagnosis was generalized BP.All patients were treated with subcutaneous injection of dupilumab,600 mg for the first time and 300 mg every 2 weeks thereafter,and according to the clinical manifestations,the traditional treatment drugs were gradually reduced and discontinued.All patients BP disease area index(BPDAI)score,body surface area(BSA)and itch numerical rating scale(NRS)scores were reduced to 0.No recurrence was observed during 6-12 months of follow-up.Conclusion Dupilumab is effective and safe in the treatment of generalized BP with multiple systemic lesions.
作者
杨晶露
郝英利
孟思宇
卢博
于子辰
陈思冉
冯玉娟
张士发
YANG Jinglu;HAO Yingli;MENG Siyu;LU Bo;YU Zichen;CHEN Siran;FENG Yujuan;ZHANG Shifa(Department of Dermatology,Northeast International Hospital,Shenyang,Liaoning 110623,China)
出处
《中国临床研究》
CAS
2024年第1期112-115,121,共5页
Chinese Journal of Clinical Research
作者简介
通信作者:张士发,E-mail:zhangshifa_1963@126.com。
