摘要
患者男,62岁,全身红斑水疱伴瘙痒1年,伴背痛、无法行走2周。患者全身反复出现红斑伴瘙痒6年,曾诊断为湿疹,长期门诊治疗。1年前部分皮疹表面出现水疱,外院经组织病理和免疫病理确诊为大疱性类天疱疮,经糖皮质激素、免疫抑制剂、静脉注射免疫球蛋白多次治疗后皮疹仍时有反复,伴明显瘙痒。随后,尝试使用度普利尤单抗600 mg皮下注射,1周后改为300 mg,随后每2周给予300 mg皮下注射。经过8次治疗后瘙痒明显缓解,皮疹均消退,停用甲氨蝶呤,后逐渐减量糖皮质激素。随访5个月,患者皮疹未复发,无不良反应,目前患者仍在门诊随访中。
A 62-year-old male presented with erythema and blisters all over the body with itching for 1 year,accompanied with back pain and inability to walk for 2 weeks.The patient was diagnosed as eczema 6 years due to recurrent systemic erythema accompanied by pruritus,and long-term outpatient visit was performed.One year ago,blisters appeared on the surface of part of the rash,which was diagnosed as bullous pemphigoid by histophiology and immunopathology in other hospitals.After repeated treatment with glucocorticoid,immunosuppressant and intravenous gamma globulin,the rash was still recurrent,accompanied by obvious itching.Subcutaneous injection of dupilumab 600 mgwas then attempted,followed by 300 mg subcutaneous injection 1 week later,and 300 mg subcutaneous injection every 2 weeks until now.After treatment,the pruritus was significantly relieved,and the rash subsided.Methotrexate was withdrawn and glucocorticoid was gradually reduced.The patient was followed up for 5 months.There was no recurrence of rash and no adverse reaction.The patient was still under the outpatient follow-up.
作者
潘春梅
潘萌
冯雨苗
丁高中
朱燕萍
孙澜
PAN Chunmei;PAN Meng;FENG Yumiao;DING Gaozhong;ZHU Yanping;SUN Lan(Department of Dermatology,the Affiliated Suzhou Hospital of Nanjing Medical University,East District of Suzhou Municipal Hospital,Suzhou 215001,China;Department of Dermatology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2022年第3期311-314,共4页
The Chinese Journal of Dermatovenereology
基金
苏州市姑苏卫生人才计划培养项目(GSWS2020071)
苏州市科技计划项目(SYS2020176)。
作者简介
通信作者:孙澜,E-mail:slszsy@126.com。
