摘要
目的探讨腹泻型肠易激综合征(IBS-D)脾虚湿盛证患者应用参苓白术散加减治疗的效果。方法选取2020年10月至2022年10月该院收治的78例IBS-D脾虚湿盛证患者为研究对象,按照随机数字表法分为观察组与对照组,各39例。对照组采用匹维溴铵治疗,观察组联合参苓白术散加减治疗,均连续治疗4周。比较两组总有效率、降钙素基因相关肽(CGRP)、血管活性肠肽(VIP)、5-羟色胺(5-HT)、胆囊收缩素(CCK)水平,以及中医证候总积分、生活质量、不良反应。结果治疗前,观察组与对照组CGRP、VIP、5-HT、CCK水平,中医证候总积分,IBS生活质量量表(IBS-QOL)评分比较,差异无统计学意义(P>0.05)。治疗后,观察组总有效率(94.87%)高于对照组(79.92%),CGRP、VIP、5-HT、CCK水平及中医证候总积分均低于对照组,IBS-QOL评分高于观察组,差异均有统计学意义(P<0.05)。两组均未见明显不良反应。结论匹维溴铵治疗基础上联合参苓白术散加减治疗IBS-D脾虚湿盛证患者效果确切,且具有良好的安全性,值得临床推广应用。
Objective To investigate the therapeutic effect of Shenling Baishu powder on patients with diarrheal irritable bowel syndrome(IBS-D)with spleen deficiency and dampness.Methods A total of 78 IBS-D with spleen deficiency and dampness patients admitted to Leping Hospital of Traditional Chinese Medicine from October 2020 to October 2022 were selected as the study objects,and were divided into observation group and control group according to random number table method,with 39 cases in each group.The control group was treated with Piveronium bromide,and the observation group was treated with Shenling Baishu powder on the basis of Piveronium bromide,all the patients were treated for 4 weeks.The total effective rate,the levels of calcitonin gene-related peptide(CGRP),vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT),cholecystokinin(CCK),the total score of TCM syndromes,quality of life and adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference on CGRP,VIP,5-HT and CCK levels,total score TCM syndromes and Quality of Life Scale(IBS-QOL)score between the observation group and the control group(P>0.05).The total effective rate of the observation group(94.87%)was higher than that of the control group(76.92%),the levels of CGRP,VIP,5-HT,CCK and total scores of TCM syndromes after treatment were lower than those of the control group,and the score of IBS-QOL was higher than that of the observation group,with statistical significance(P<0.05).No obvious adverse reaction was observed in the two groups.Conclusion The combination of Piveronium bromide and Shenling Baishu powder in the treatment of patients with IBS-D with spleen deficiency and dampness has a definite effect and good safety,which is worthy of clinical promotion and application.
作者
徐博文
徐海丰
程晨
XU Bowen;XU Haifeng;CHENG Chen(Department of Spleen and Stomach,Leping Hospital of Traditional Chinese Medicine,Jingdezhen,Jiangxi 333300,China;Department of Cardiology,Leping Hospital of Traditional Chinese Medicine,Jingdezhen,Jiangxi 333300,China)
出处
《检验医学与临床》
2024年第4期530-532,537,共4页
Laboratory Medicine and Clinic
关键词
腹泻型肠易激综合征
脾虚湿盛证
参苓白术散加减
胃肠激素
生活质量
安全性
diarrheal irritable bowel syndrome
syndrome of spleen deficiency and dampness
Shenling Baishu powder
gastrointestinal hormone
quality of life
security
作者简介
徐博文,男,主治中医师,主要从事消化道疾病中医诊疗研究。
