摘要
目的分析在慢性心力衰竭合并心房颤动用比索洛尔联合地高辛治疗后的临床疗效及安全性。方法纳入我院2021年1月—2022年12月收治的150例慢性心力衰竭合并心房颤动患者,以随机数字表法分为观察组(比索洛尔+地高辛+常规治疗,75例)与对照组(常规治疗+地高辛,75例),比较分析两组治疗前后心功能[心搏输出量(SV)、左室射血分数(LVEF)]、心房颤动率(最大心室率、最小心室率、平均心室率)、心力衰竭相关指标[血浆N末端B型脑钠肽前体(NT-ProBNP)、肌酸激酶(CK)]、心肌能量代谢状态[心肌能量消耗(MEE)];分析两组治疗后临床总有效率及不良反应发生率(头晕、嗜睡、胃肠道反应)。结果治疗前,两组心功能、心房颤动率、心力衰竭指标、心肌能量代谢状态比较均无统计学差异(均P>0.05)。治疗后,观察组心功能高于对照组,心房颤动率、心力衰竭指标、心肌能量代谢状态低于对照组(P<0.05);观察组临床总有效率高于对照组(P<0.05);两组不良反应对比无统计学差异(P>0.05)。结论比索洛尔联合地高辛在慢性心力衰竭合并心房颤动治疗中,能显著提高心功能,减少心房颤动,较单纯地高辛治疗能更有助于改善心肌能量代谢,且未明显增加不良反应,安全性较好。
Objective To analyze the clinical efficacy and safety of bisoprolol combined with digoxin in the treatment of chronic heart failure complicated with atrial fibrillation.Methods A total of 150 patients with chronic heart failure(HF)combined with atrial fibrillation admitted to our hospital from January 2021 to December 2022 were included,and were divided into the observation group(bisoprolol+digoxin+conventional treatment,75 cases)and the control group(conventional treatment+digoxin,75 cases)with a randomized numerical table method,and compared and analyzed before and after the treatment of the two groups in terms of cardiac function(cardiac stroke output(SV),left ventricular ejection fraction(LVEF),atrial fibrillation rate(maximum ventricular rate,minimum ventricular rate,average ventricular rate),HF-related indexes[plasma N-terminal B-type brain natriuretic peptide precursor(NT-ProBNP),creatine kinase(CK)],and myocardial energy metabolic status[myocardial energy expenditure(MEE)];and analyze the total clinical effectiveness rate and the incidence rate of adverse reactions after treatment in the two groups(dizziness,drowsiness,gastrointestinal reactions).Results Before treatment,there was no statistical difference in the comparison of cardiac function,atrial fibrillation rate,HF indexes,and myocardial energy metabolic state between the two groups(all P>0.05).After treatment,the observation group's cardiac function was higher than that of the control group,and the rate of atrial fibrillation,HF indexes,and myocardial energy metabolism status were lower than that of the control group(P<0.05);the total clinical effectiveness rate of the observation group was higher than that of the control group(P<0.05);and there was no statistical difference in the adverse reactions of the two groups(P>0.05).Conclusions Bisoprolol combined with digoxin in the treatment of chronic HF combined with atrial fibrillation,can significantly improve cardiac function,reduce atrial fibrillation,comparing to pure digoxin treatment,can help to improve myocardial energy metabolism,and did not increase obvious adverse reactions,and have a good safety.
作者
陈石涛
刘华
CHEN Shitao;LIU Hua(Department of Cardiovascular Medicine,Wuping County Hospital,Longyan 364300,China)
出处
《中国医药指南》
2024年第5期74-77,共4页
Guide of China Medicine
关键词
比索洛尔
地高辛
慢性心力衰竭
心房颤动
Bisoprolol
Digoxin
Chronic heart failure
Atrial fibrillation
