摘要
目的探讨盐酸贝那普利联合比索洛尔治疗高血压并冠心病的临床疗效。方法选取茂名市中医院2015年12月—2018年1月收治的高血压并冠心病患者共80例,随机分为对照组和观察组,各40例。对照组给予盐酸贝那普利治疗,观察组在对照组基础上给予比索洛尔治疗,两组均持续治疗6个月。比较两组治疗前后收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);并观察两组治疗期间不良心血管事件发生率。结果治疗前两组SBP、DBP比较,差异无统计学意义(P>0.05);治疗后观察组SBP、DBP低于对照组(P<0.05)。治疗前两组TG、TC、HDL-C和LDL-C比较,差异无统计学意义(P>0.05);治疗后观察组TG、TC、LDL-C低于对照组,HDL-C高于对照组(P<0.05)。两组不良心血管事件发生率比较,差异无统计学意义(P>0.05)。结论盐酸贝那普利联合比索洛尔治疗高血压并冠心病的临床疗效确切,可有效降低血压和血脂,且安全性较高。
Objective To explore the clinical effect of benazepril hydrochloride combined with bisoprolol for hypertension and coronary disease.Methods A total of 80 cases of patients with hypertension and coronary disease were selected from the December 2015 to January 2018 in Maoming Hospital of Traditional Chinese Medicine,which were randomly divided into control group and observation group,40 cases each of groups.The control group was treated with benazepril hydrochloride,and the observation group was treated with bisoprolol based on the control group.Both groups were treated for 6 months.SBP,DBP,TG,TC,HDL-C and LDL-C were compared before and after treatment,and the incidence rate of adverse cardiovascular events was observed.Results There was no significant difference in SBP and DBP between the two groups before treatment(P>0.05);after treatment,SBP and DBP in the observation group were lower than the control group(P<0.05).There was no significant difference in TG,TC,HDL-C and LDL-C between the two groups before treatment(P>0.05);after treatment,TG,TC and LDL-C in the observation group were lower than the control group,and HDL-C was higher than the control group(P<0.05).There was no significant difference in the incidence rate of adverse cardiovascular events between the two groups(P>0.05).Conclusion Benazepril hydrochloride combined with bisoprolol for hypertension and coronary disease has definite clinical effect,it can effectively reduce blood pressure and blood lipid,and with high safety.
作者
程海生
杨文静
CHENG Hai-sheng;YANG Wen-jing(Department of Cardiology,Maoming Hospital of Traditional Chinese Medicine,Maoming 525000,China)
出处
《临床合理用药杂志》
2020年第3期13-14,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
高血压
冠心病
盐酸贝那普利
比索洛尔
治疗结果
Hypertension
Coronary disease
Benazepril hydrochloride
Bisoprol
Treatment outcome
