摘要
Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.
基金
the National Natural Science Foundation of China(NSFC,Nos.32171318,32222090 and 32101069)
the Faculty of Health Sciences,University of Macao,the Multi-Year Research Grant(MYRG)of University of Macao(No.MYRG2022-00011-FHS)
the Science and Technology Development Fund,Macao SAR(Nos.0103/2021/A and 0002/2021/AKP)
Shenzhen Science and Technology Innovation Commission,Shenzhen-Hong Kong-Macao Science and Technology Plan C(No.SGDX20201103093600004)
Dr.Stanley Ho Medical Development Foundation(No.SHMDF-OIRFS/2022/002)。
作者简介
Songtao Zhou,contributed equally to this work;Hao Tian,contributed equally to this work;Corresponding author:Jie Song Corresponding author at:Jie Song,Cancer Center and Institute of Translational Medicine,Faculty of Health Sciences,University of Macao,Macao 999078,China.E-mail addresses:sjie@sjtu.edu.cn;Corresponding author at:Yunlu Dai,Cancer Center and Institute of Translational Medicine,Faculty of Health Sciences,University of Macao,Macao 999078,China.E-mail addresses:yldai@um.edu.mo。
