摘要
目的:观察益气托毒法治疗慢性创面的临床疗效。方法:选取2020年12月—2022年1月广西中医药大学第一附属医院收治的慢性创面患者48例,随机分为治疗组及对照组,每组24例。对照组给予常规消毒后进行局部创面清创并予以湿润烧伤膏外用;治疗组在对照组的基础上予以托里消毒散水煎内服,两组疗程均为2周。治疗前后根据创面面积、渗液情况、腐脱程度、肉芽色泽情况评分后,进行临床疗效评价。结果:与治疗前相比,两组患者创面面积、渗液情况、腐脱程度、肉芽色泽情况积分均有所下降,差异具有统计学意义(P<0.05);与对照组相比,治疗2周后,治疗组总有效率95.8%(23/24),对照组总有效率75.0%(18/24),差异具有统计学意义(P<0.05),治疗组疗效更优,且治疗后治疗组创面白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量明显低于对照组(P<0.05)。结论:托里消毒散能够缩小创面面积,减少创面渗液、创面腐肉,改善肉芽色泽情况,加快创面愈合速度,作用机制可能与其降低IL-1β、IL-6、TNF-α炎症因子表达水平相关。
Objective:to observe the clinical curative effect of qi-replenishing and toxin-expelling method on the treatment of chronic wounds.Methods:Forty-eight patients with chronic wounds were selected from The First Affiliated Hospital of Guangxi Medical University from December 2020 to January 2022 and were randomly divided into treatment group and control group,24 patients in each group.The control group received routine disinfection followed by local wound debridement and topical application of Moist Exposed Burn Ointment(MEBO);while,the treatment group was administered orally Tuoli disinfection powder decocted with water.The treatment course of both groups was 2 weeks.Before and after the treatment,the clinical effect was evaluated according to the wound area,the state of fluid seepage,the degree of decay,and the color of granulation.The wound area,fluid seepage,decay degree and granulation color scores of the two groups were decreased compared with those before the treatment,and the differences were statistically significant(P<0.05,P<0.01).Results:The wound area,fluid seepage,decay degree and granulation color scores of the two groups were decreased compared with those before the treatment,and the differences were statistically significant(P<0.05,P<0.01).Two weeks after the treatment,the total effective rate of the treatment group was 95.8%(23/24)and the total effective rate of the control group was 75.0%(18/24),the difference was statistically significant(P<0.05),and the curative effect of the treatment group was superior to control group.The contents of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the treatment group were significantly lower than those in the control group(P<0.05)after the treatment.Conclusions:Tuoli disinfection powder can reduce wound area,reduce wound exudation and rotting flesh,improve granulation color,and accelerate wound healing.This effect may be related to the reduction of expression level of inflammatory factors IL-1β,IL-6,TNF-α.
作者
贺璇
李杰辉
李恒嫦
梁彬
卢维
陈红枫
刘明
狄钾骐
HE Xuan;LI Jiehui;LI Hengchang;LIANG Bin;LU Wei;CHEN Hongfeng;LIU Ming;DI Jiaqi(Graduate College of Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《中医药学报》
CAS
2024年第2期58-61,共4页
Acta Chinese Medicine and Pharmacology
基金
广西中医药大学研究生教育创新计划项目(YCXJ2021079)。
关键词
慢性创面
益气托毒法
托里消毒散
临床疗效
炎症因子
Chronic wound area
Qi-replenishing and toxin-expelling method
Tuoli disinfection powder
Clinical efficacy
Inflammatory factor
作者简介
贺璇(1997-),女,硕士研究生,研究方向:创面修复的中西医结合基础与临床研究。;通讯作者:李杰辉(1981-),男,硕士,教授,硕士研究生导师,研究方向:创面修复的中西医结合基础与临床研究。
