摘要
目的 探究治疗消化道早癌中采用内镜黏膜下剥离术的效果。方法 回顾性选取2021年1月—2023年1月单县海吉亚医院收治的90例消化道早期癌症患者的临床资料,根据治疗方法分成研究组(内镜黏膜下剥离术)与对照组(内镜黏膜切除术),各45例,对比患者术后恢复情况。结果 研究组治愈率为97.78%(整块切除率为97.78%,横向切缘阴性率为100%,纵向切缘阴性率95.56%)较对照组治愈率84.44%高(整块切除率为86.67%,横向切缘阴性率为91.11%,纵向切缘阴性率82.22%),差异有统计学意义(P<0.05);此外,研究组手术相关指标均较对照组佳,差异有统计学意义(P<0.05);治疗后,研究组的去甲肾上腺素和皮质醇水平明显低于对照组,差异有统计学意义(P<0.05),但两组癌胚抗原和糖类抗原125指标结果没有差异,差异无统计学意义(P>0.05)。此外,研究组术后并发症发生率为2.22%小于对照组17.77%的发生率,差异有统计学意义(χ^(2)=6.049,P<0.05);研究组术后疼痛情况表现较对照组低,差异有统计学意义(P<0.05)。结论 内镜黏膜下剥离术可以彻底切除癌组织,同时改善应激水平,并且防止术后并发症的发生,在治疗消化道早癌方面具有良好的疗效。
Objective To investigate the effect of endoscopic submucosal dissection in the treatment of early gastroin-testinal cancer.Methods From January 2021 to January 2023,90 patients of clinical data with early gastrointestinal cancer admitted to Shanxian Haijiya Hospital were retrospectively selected.According to the treatment methods,they were divided into the study group(endoscopic submucosal dissection)and the control group(endoscopic mucosal re-section),with 45 cases in each group.The postoperative recovery of patients was compared.Results The cure rate of the study group was 97.78%(en bloc resection rate was 97.78%,transverse resection margin negative rate was 100.00%,longitudinal resection margin negative rate was 95.56%),which was higher than 84.44%of the control group(en bloc resection rate was 86.67%,transverse resection margin negative rate was 91.11%,longitudinal resection mar-gin negative rate was 82.22%),the difference was statistically significant(P<0.05).In addition,the surgery-related in-dicators of the study group were better than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of norepinephrine and cortisol in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05),but the results of carcinoembry-onic antigen and carbohydrate antigen 125 were not different between the two groups,and the differences were not sta-tistically significant(P>0.05).In addition,the incidence of postoperative complications in the study group was 2.22%,which was lower than 17.77%in the control group,and the difference was statistically significant(χ^(2)=6.049,P<0.05).The postoperative pain of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Endoscopic submucosal dissection can completely remove cancerous tissues while improving the stress level and preventing postoperative complications,which has good efficacy in the treatment of early gastrointestinal cancer.
作者
刘涛
LIU Tao(Department of Gastroenterology,Shanxian Haijiya Hospital,Heze,Shandong Province,274300 China)
出处
《中外医疗》
2023年第34期68-71,共4页
China & Foreign Medical Treatment
关键词
内镜黏膜下剥离术
消化道早癌
安全性
治疗效果
Endoscopic submucosal dissection
Early gastrointestinal cancer
Safety
Therapeutic effect
作者简介
刘涛(1983-),男,本科,副主任医师,研究方向为消化内科学。
