摘要
目的探讨基于产后出血预测评分的个性化用药方案预防剖宫产产后出血的效果及对凝血纤溶功能的影响。方法选取2018年6月至2021年6月收治的150例剖宫产产妇作为研究对象,将其随机分为对照组和观察组,每组75例。对照组采用益母草注射液、卡前列素氨丁三醇和缩宫素治疗,观察组采用基于产后出血预测评分的个性化用药方案治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组(P<0.05)。术后2、24 h,观察组的出血量少于对照组(P<0.05);术后3、7 d,观察组的宫底高度低于对照组(P<0.05)。术后24 h,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组,纤维蛋白降解产物(FDP)水平低于对照组,纤溶酶原激活剂抑制物-1(PAI-1)、抗凝血酶-Ⅲ(AT-Ⅲ)水平高于对照组(P<0.05)。术后24 h,观察组的过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)水平高于对照组,活性氧(ROS)水平低于对照组(P<0.05)。结论基于产后出血预测评分的个性化用药方案有助于提高剖宫产产后出血预防效果,减少产后出血量,促进宫底高度恢复,有效改善凝血纤溶功能,也能减轻氧化应激反应,值得推广。
Objective To investigate the effect of personalized medication regimen based on postpartum hemorrhage prediction score on prevention of postpartum hemorrhage after cesarean section and its influence on coagulation and fibrinolysis function.Methods A total of 150 parturients with cesarean section admitted from June 2018 to June 2021 were selected as the research objects and randomly divided into control group and observation group,with 75 cases in each group.The control group was treated with motherwort injection,carboprost tromethamine and oxytocin,and the observation group was treated with personalized medication regimen based on postpartum hemorrhage prediction score.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).At 2 and 24 h after operation,the amount of bleeding in the observation group was less than that in the control group(P<0.05);at 3 and 7 d after operation,the uterine fundus height in the observation group was lower than that in the control group(P<0.05).At 24 h after operation,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,the level of fibrin degradation product(FDP)was lower than that in the control group,and the levels of plasminogen activator inhibitor-1(PAI-1)and antithrombin-Ⅲ(AT-Ⅲ)were higher than those in the control group(P<0.05).At 24 h after operation,the levels of catalase(CAT)and glutathione peroxidase(GSH-Px)in the observation group were higher than those in the control group,and the level of reactive oxygen species(ROS)was lower than that in the control group(P<0.05).Conclusion The personalized medication regimen based on the postpartum hemorrhage prediction score is helpful to improve the prevention effect of postpartum hemorrhage after cesarean section,reduce the amount of postpartum hemorrhage,promote the recovery of uterine fundus height,effectively improve the coagulation and fibrinolysis function,and also reduce the oxidative stress reaction,which is worthy of promotion.
作者
陈艳
党媛
李冰
CHEN Yan;DANG Yuan;LI Bing(the First Hospital in Weinan,Weinan 714000;Weinan Maternal and Child Health Hospital,Weinan 714000,China)
出处
《临床医学研究与实践》
2024年第3期78-82,共5页
Clinical Research and Practice
关键词
产后出血预测评分
个性化用药方案
剖宫产
产后出血
凝血纤溶功能
postpartum hemorrhage prediction score
personalized medication regimen
cesarean section
postpartum hemorrhage
coagulation and fibrinolysis function
作者简介
陈艳(1977-),女,副主任医师。研究方向:产科妊娠期糖尿病;通讯作者:党媛,E-mail:1360001420@qq.com.
