摘要
目的观察产后静脉滴注缩宫素联合宫颈注射卡前列素氨丁三醇注射液预防产妇产后出血的效果。方法将70例自然分娩产妇按随机数字表法分为观察组37例和对照组33例,对照组于胎儿娩出后常规给予缩宫素20 U静脉滴注治疗,观察组在对照组基础上给予宫颈注射卡前列素氨丁三醇注射液治疗。比较2组产妇产后不同时点总出血量和产后出血发生率,比较2组用药前后血流动力学指标变化和产后血红蛋白(Hb)、红细胞(RBC)水平变化,并比较2组用药后不良反应发生情况。结果观察组产后2、24 h总出血量均少于对照组,产后出血发生率低于对照组,差异有统计学意义(P<0.05);用药后,观察组心率(HR)低于对照组,收缩压(SBP)、舒张压(DBP)和平均动脉压(MAP)均高于对照组,差异有统计学意义(P<0.05);产后,观察组Hb下降值和RBC下降值低于对照组,差异有统计学意义(P<0.05);2组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论产后静脉滴注缩宫素联合宫颈注射卡前列素氨丁三醇注射液对预防产妇产后出血具有良好效果,可减少产妇产后出血量,降低产后出血发生率,改善血流动力学指标,且不会增加不良反应,安全性较好。
Objective To observe clinical effect of oxytocin combined with cervical injection of carprost and ambutetriolin in preventing postpartum hemorrhage.Methods A total of 70 women with natural childbirth were divided into observation group(n=37)and control group(n=33)according to random number table method.The control group received conventional intravenous infusion of 20 U oxytocin after delivery.On this basis,the observation group were injected carprost and ambutetriolin into the cervix.The total bleeding volume and the incidence of postpartum hemorrhage were compared between the two groups at different postpartum time points.Changes in hemodynamic indexes,hemoglobin(Hb)and red blood cell(RBC)levels before and after medication were compared,and adverse reactions after medication were recorded.Results At 2 and 24 h after delivery,the total bleeding volume of the observation group was significantly less than that of the control group,and the incidence of postpartum hemorrhage was significantly lower than that in the control group(P<0.05).After medication,the observation group had lower heart rate(HR),higher systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean arterial pressure(MAP)than the control group(P<0.05).Besides,the decreased value of Hb and RBC were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of total adverse reactions between the two groups(P>0.05).Conclusion Postpartum intravenous infusion of oxytocin combined with cervical injection of carprost and ambutetriolin is effective in preventing postpartum hemorrhage,which can significantly deerease the bleeding volume,reduce the incidence of postpartum hemorrhage,and improve the hemodynamic indicators without increasing adverse reactions,and the combined therapy has higher safety.
作者
李思梅
王赵伟
LI Simei;WANG Zhaowei(Department of Obstetrics and Gynecology,West Division of Hefei City First People′s Hospital of Anhui Province,Anhui,Hefei,230011;Department of Gynecology,Xiamen City Fifth Hospital of Fujian Province,Xiamen,Fujian,361101)
出处
《实用临床医药杂志》
CAS
2021年第10期99-102,共4页
Journal of Clinical Medicine in Practice
基金
福建省厦门市医疗卫生科技计划项目(3502Z20194090)。
关键词
自然分娩
产后出血
卡前列素氨丁三醇注射液
止血
血流动力学
natural labor
postpartum hemorrhage
carprost and ambutetriolin injection
hemostasis
hemodynamics
作者简介
通信作者:王赵伟,E-mail:15859234545@126.com。
