摘要
目的:观察半夏泻心汤对脾胃湿热型儿童幽门螺杆菌(helicobacter pylori,HP)感染相关性胃炎的临床疗效,并观察其对相关炎症因子的影响。方法:71例脾胃湿热型Hp感染相关性胃炎患儿按照随机数字表随机分为治疗组35例和对照组36例。对照组脱落6例,纳入研究30例;治疗组脱落4例,纳入研究31例。对照组给予西药三联疗法,治疗组在对照组治疗基础上给予半夏泻心汤。两组疗程均为14 d。比较两组患儿治疗后的有效率、Hp根除率、中医证候积分和炎症因子水平。结果:(1)治疗组有效率为96.77%(30/31),对照组为73.33%(22/30),两组比较,差异有统计学意义(P<0.05)。(2)治疗后,治疗组Hp根除率为83.87%(26/31),对照组为43.33%(13/30),两组比较,差异有统计学意义(P<0.05)。(3)治疗后,两组患儿胃脘疼痛、胃脘痞满、胃脘灼热、口苦口干、恶心呕吐、大便稀溏等证候积分显著下降(P<0.05),治疗组以上指标低于同期对照组(P<0.05)。(4)治疗后,两组患儿白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α及超敏C反应蛋白水平显著下降(P<0.01),治疗组以上指标低于同期对照组(P<0.01)。结论:半夏泻心汤联合西药三联疗法治疗脾胃湿热型儿童Hp感染相关性胃炎患儿疗效显著,可有效缓解患儿胃脘疼痛、胃脘痞满、胃脘灼热、口苦口干、恶心呕吐、大便稀溏等症状,其症状改善可能与降低患儿体内炎症因子水平有关。
Objective:To observe the clinical efficacy of Banxia Xiexin Decoction on helicobacter pylori(HP)infection associated gastritis in children with Spleen and Stomach Damp Heat syndrome and to observe its impact on related inflammatory factors.Method:71 children with Spleen and Stomach Damp Heat type Helicobacter pylori infection related gastritis were randomly divided into a treatment group of 35 cases and a control group of 36 cases according to a random number table.There were 6 cases excluded from the control group and 30 cases included in the study.There were 4 cases of dropout in the treatment group and 31 cases were included in the study.The control group received triple therapy with western medicine,while the treatment group received Banxia Xiexin Decoction in addition to the control group′s treatment.Both treatment groups have a duration of 14 days.The effective rate,Hp eradication rate,traditional Chinese medicine syndrome score,and levels of inflammatory factors between two groups of children after treatment were compared.Results:(1)The effective rate of the treatment group was 96.77%(30/31),while that of the control group was 73.33%(22/30).The difference between the two groups was statistically significant(P<0.05).(2)After treatment,the Hp eradication rate in the treatment group was 83.87%(26/31),while in the control group it was 43.33%(13/30).The difference between the two groups was statistically significant(P<0.05).(3)After treatment,the scores of symptoms such as epigastric pain,epigastric fullness,epigastric burning,bitter and dry mouth,nausea and vomiting,and loose stools in both groups of patients significantly decreased(P<0.05).The above indicators in the treatment group were lower than those in the control group during the same period(P<0.05).(4)After treatment,two groups of children were treated with interleukin-6,interleukin-8,and tumor necrosis factor-α.The levels of high-sensitivity C-reactive protein significantly decreased(P<0.01),and the above indicators in the treatment group were lower than those in the control group during the same period(P<0.01).Conclusion:The combination of Banxia Xiexin Decoction and western medicine triple therapy has a significant therapeutic effect on children with Helicobacter pylori infection related gastritis of Spleen and Stomach Damp Heat syndrome.It can effectively alleviate symptoms such as epigastric pain,epigastric fullness,epigastric burning,bitter and dry mouth,nausea and vomiting,loose stools,etc.The improvement of symptoms may be related to reducing the level of inflammatory factors in child.
作者
张见男
马淑霞
郭振鑫
ZHANG Jiannan;MA Shuxia;GUO Zhenxin(School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2024年第2期411-415,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2019ZY2075)。
关键词
胃炎
幽门螺杆菌
脾胃湿热证
半夏泻心汤
儿童
中医证候
炎症因子
gastritis
helicobacter pylori
Spleen and Stomach Damp Heat syndrome
Banxia Xiexin Decoction
children
traditional Chinese medicine syndrome
inflammatory factor
作者简介
张见男(1995-),女,河南济源人,医学硕士,研究方向:中医药防治小儿感染与消化疾病研究;通信作者:马淑霞,女,主任医师。E-mail:msx1562@126.com。
