摘要
随着糖皮质激素在临床的广泛应用,激素性股骨头坏死(Steroid induced Avascular Necrosis of Femoral Head,SANFH)的发病率也随之逐年升高,但就其具体的发病机制尚不明确,因此探究其发病机制非常必要。研究发现糖皮质激素的长期及短期大量使用会导致股骨头凝血功能障碍、脂代谢紊乱、骨内压增高、细胞程序性坏死等,相关信号通路如wnt/β-catenin、RANKL-RANK、PTEN/AKT、PI3K/AKT等也在其中起着关键的作用,最终导致SANFH的发生,因此探究SANFH的具体发病机制,对临床防治SANFH具有重要意义。
With the wide application of glucocorticoid in clinical practice,the incidence rate of steroid induced avascular necrosis of femoral head(SANFH)has increased year by year,but its specific pathogenesis is still unclear,so it is necessary to explore its pathogenesis.Research has found that long-term and short-term excessive use of glucocorticoids can lead to coagulation dysfunction,lipid metabolism disorders,increased bone pressure,and programmed cell necrosis of the femoral head.Relevant signaling pathways such as wnt/β-catenin,RANKL-RANK,PTEN/AKT,PI3K/AKT,etc.also play a key role in this process,ultimately leading to the occurrence of SANFH.Therefore,exploring the specific pathogenesis of SANFH is of great significance for clinical prevention and treatment of SANFH.
作者
李纪书
郭成龙
任行全
柴威涛
赵建栋
毕煦昆
LI Jishu;GUO Chenglong;REN Xingquan;CHAI Weitao;ZHAO Jiandong;BI Xukun(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《现代中医药》
2024年第1期5-10,共6页
Modern Chinese Medicine
基金
张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号)
甘肃省中管局项目(GZKP-2022-20)
兰州市卫生健康委员会项目(2021033)。
关键词
激素性股骨头坏死
发病机制
信号通路
Steroid induced avascular necrosis of femoral head
Pathogenesis
Signal pathway
作者简介
通讯作者:郭成龙,主任医师。E-mail:107228466@qq.com。
