摘要
目的:探究阿尔茨海默病(AD)患者氧化型低密度脂蛋白(ox-LDL)和胆碱酯酶(CHE)检测的临床意义。方法:选取2018年4月~2021年4月广东医科大学附属医院附属医院收治的AD患者36例作为观察组,另选取同期健康者36例作为对照组,分别检测和比较两组血清的ox-LDL和CHE水平差异,并结合患者实际病情进行对照分析。结果:观察组的ox-LDL高于对照组,而CHE低于对照组,差异有统计学意义(P<0.05);AD患者病情程度不同其检测因子含量亦不同,CHE呈下降趋势、ox-LDL呈上升趋势。结论:ox-LDL和CHE的血清水平与AD有一定的相关性,并可对AD患者的病情程度进行预测。
Objective To explore the clinical significance of ox-LDL and CHE in patients with Alzheimer's Disease(AD).Methods A total of 36 patients with AD from Affiliated Hospital of Guangdong Medical University were randomly selected as the observation group,in addition,36 healthy check-up were selected as the control group,Serum ox-LDL and CHE levels of the two groups were detected respectively.Results The serum ox-LDL in the observation group were higher than that of control group(P<0.05),but CHE was lower(P<0.05).The contents of detection factors were different with different degrees of disease,CHE showed a downward trend and ox-LDL showed an upward trend.Conclusion The serum levels of ox-LDL and CHE were closely correlated with the severity in AD,and the level of their content is related to the degree of disease,which is of clinical significance.
作者
陈育华
孙元中
周碧云
梁斯锶
CHEN Yu-Hua;SUN Yuan-Zhong;ZHOU Bi-Yun(Department of Clinical Laboratory,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong,China)
出处
《吉林医学》
CAS
2024年第1期27-30,共4页
Jilin Medical Journal
基金
广东省医学科学技术研究基金项目[项目编号:B2019172]。
