摘要
牙体粘接修复过程中,树脂与牙本质纤维形成混合层的稳定性对修复效果有重要影响。宿主源性蛋白酶对胶原纤维的水解是导致混合层破坏,粘接修复失败的常见原因。研究显示壳聚糖及其衍生物作为新型生物材料,可通过促进胶原交联及抑制蛋白酶活性增强混合层的稳定性从而提升粘接修复的强度及耐久性,因而在牙本质粘接修复领域有广泛应用前景。该文就壳聚糖及其衍生物的性质、作用机制及其在牙本质粘接领域应用的研究进展作一综述。
The stability of the hybrid layer formed by adhesive resin systems and dentin collagen fibrils is critical to the success of dentine restoration.The hydrolysis of dentin collagen fibrils by endogenous dentin proteases is responsible for the failure of dentin bonding.Studies have shown than chitosan and its derivatives,as an innovative biomaterial in dentin bonding,could enhance dentin bond strength and the durability of resin-dentin bond.This article reviewed the properties,mechanism and research progress of chitosan and its derivatives in dentin bonding.
作者
关岚曦
蔡辰
黄雨婷
李阳
江千舟
GUAN Lanxi;CAI Chen;HUANG Yuting;LI Yang;JIANG Qianzhou(Department of Endodontics,Affiliated Stomatology Hospital of Guangzhou Medical University,Guangdong Engineering Research Center of Oral Restoration and Reconstruction,Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine,Guangzhou 510182,China)
出处
《口腔医学》
CAS
2023年第12期1129-1133,共5页
Stomatology
基金
广东省科研事业单位重点领域研发计划(2020B1111490004)
广东省科技创新战略专项资金(2021A1515010870)
广州医科大学2022年度学生创新能力提升计划(02-408-2203-2074)。
作者简介
通信作者:江千舟,Tel:(020)61350524,E-mail:jqianzhou@126.com。
