摘要
基质金属蛋白酶(MMP)能够降解牙本质胶原纤维,是影响牙科粘接修复耐久性的重要因素。因此,抑制牙本质MMP的活性是提高粘接耐久性的关键。作为一种MMP抑制剂,交联剂不仅能够抑制MMP活性,还具备促进牙本质胶原纤维交联的作用,上述双重作用使交联剂能够提高牙本质粘接的耐久性。本文就常见交联剂在抑制MMP与提高牙本质粘接耐久性方面的研究进展进行综述。
The matrix metalloproteinases(MMPs)can degrade dentin collagen fibers,which plays an important role in affecting the bonding durability of dental restoration.Therefore, inhibiting the activity of dentin MMPs is the key to improve bonding durability.As inhibitors of MMPs,cross-linking agents can not only inhibit the activity of MMPs,but also promote the crosslinking of dentin collagen fibers.These two functions enable cross-linkers to improve dentin bonding.In this article, the research progress of common cross - linking agents in inhibiting MMPs and improving bonding durability of dentin was reviewed.
作者
鄢晓媛
陈玥
李轲
郑适泽
战德松
付佳乐
Yan Xiaoyuan;Chen Yue;Li Ke;Zheng Shize;Zhan Desong;Fu Jiale(School of Stomatology,China Medical University,Shenyang 110002,China;School of Stomatology,Jilin University,Changchun 130021,China;Department of Dental MaterialsScience,The 2^nd Department of Prosthodontics,School &Hospital of Stomatology,China Medical University,Shenyang 110002,China)
出处
《中华口腔医学研究杂志（电子版）》
CAS
2019年第5期311-316,共6页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
2018年中国医科大学大学生创新创业训练项目（1111251703）
中国医科大学新教师基金(XZR20160015)~~
关键词
基质金属蛋白酶类
酶抑制剂
交联试剂
牙本质粘接剂
牙粘合
粘接耐久性
Matrix metalloproteinases
Enzymeinhibitors
Cross-linking reagents
Dentin bonding agents
Dental bonding
Bonding durability
作者简介
通信作者:付佳乐,电子邮箱:fullers@126.com.
