摘要
目的:探讨深部浸润型子宫内膜异位症(DIE)患者血清纤溶酶原激活物抑制因子-1(PAI-1)、白细胞介素-33(IL-33)水平及与腹腔镜手术治疗效果关系。方法:选取2017年1月-2022年1月本院收治的126例DIE患者进行回顾性分析,均行腹腔镜手术,依据治疗效果分为无效组、有效组。比较两组基线资料、术前血清PAI-1、IL-33水平;应用logistic回归分析探究血清PAI-1、IL-33水平与腹腔镜手术治疗效果关系;Pearson相关性分析探讨DIE患者血清PAI-1、IL-33水平间相关性;受试者工作特征(ROC)曲线分析血清PAI-1、IL-33水平对患者腹腔镜手术治疗效果的预测效力。结果:126例经腹腔镜手术治疗后无效19例(15.1%)纳入无效组;部分缓解33例(26.2%),完全缓解74例(58.7%),纳入有效组。无效组术前血清PAI-1(224.09±36.58 mg/L)、IL-33(110.74±20.64 ng/L)水平均高于有效组(170.95±31.63 mg/L、75.36±17.72 ng/L);Pearson相关性分析显示,血清PAI-1与IL-33水平呈正相关,且均与腹腔镜手术治疗效果相关(均P<0.05)。绘制ROC曲线,患者血清PAI-1、IL-33均可预测腹腔镜手术治疗效果,二者联合预测效力最高,曲线下面积为0.948。结论:DIE患者血清PAI-1、IL-33水平异常升高,且均与腹腔镜手术治疗效果有关,二者联合检测可为治疗效果预测提供一定依据。
Objective:To investigate the correlation between the levels of serum plasminogen activator inhibitor 1(PAI 1)and interleukin 33(IL 33)of patients with deep infiltrating endometriosis(DIE)and their treatment of laparoscopic surgery.Methods:126patients with DIE l from January 2017to January 2022were analyzed retrospectively.All the patients had undergone laparoscopic surgery and were divided into group A(patients without efficacy after treatment)and group B(patients with efficacy after treatment)according to the treatment results.The baseline data,and the preoperative serum PAI 1and IL 33levels of the patients were compared between the two groups.Logistic regression analysis was used to explore the correlation between the serum PAI 1and IL 33levels of the patients and their efficacy after laparoscopic surgery.Pearson correlation analysis was used to explore the correlation between the serum PAI 1 level of the patients with DIE and their IL 33level.Receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of the serum PAI 1and IL 33levels of the patients for their therapeutic effect after laparoscopic surgery.Results:In 126patients treated by laparoscopic surgery,there were 19(15.1%)cases in group A,and there were 33cases(26.2%)with partial remission and 74cases(58.7%)with complete remission in group B.The levels of preoperative serum PAI 1(224.09±36.58mg/L)and IL 33(110.74±20.64ng/L)of the patients in group A were significantly higher than those(170.95±31.63 mg/L and 75.36±17.72ng/L)of the patients in group B.Pearson correlation analysis showed that the serum PAI 1level of the patients with DIE was positively correlated with their IL 33level,and both the serum PAI 1and IL 33levels of the patients were associated with their efficacy of the laparoscopic surgery(all P<0.05).ROC curve drawn showed that both of the serum PAI 1and IL 33levels of the patients with DIE could predicting their efficacy of laparoscopic surgical treatment,and the combined serum PAI 1and IL 33 levels of the patients with DIE had the highest predictive effectiveness,and with the area under the curve of 0.948.Conclusion:The levels of serum PAI1and IL 33of the patients with DIE increase abnormally,both of which are related to the therapeutic effect of laparoscopic surgery of the patients.The combined detections of the levels of serum PAI1 and IL 33of the patients can provide some evidences for predicting their therapeutic effect.
作者
王小兰
夏凌燕
赵维英
WANG Xiaolan;XIA Lingyan;ZHAO Weiying(Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University,Nanjing,Jiangsu Province,210000)
出处
《中国计划生育学杂志》
2023年第12期2952-2956,共5页
Chinese Journal of Family Planning
