摘要
目的:观察血栓通注射液联合常规西药治疗心血瘀阻证稳定型冠心病心绞痛的临床疗效。方法:选取114例心血瘀阻证稳定型冠心病心绞痛患者为研究对象,按随机数字表法分为对照组及联合组各57例。对照组给予常规西药治疗,联合组给予血栓通注射液联合常规西药治疗。比较2组治疗前后24 h动态心电图[室性早搏发生次数、ST段下移幅度、R-R间期的标准差(SDNN)、R-R间期差值的均方平方根(RMSSD)]、血管内皮功能指标[一氧化氮(NO)、内皮生长因子(VEGF)、内皮素(ET)]和血小板活化功能指标[血小板膜蛋白-140 (GMP-140)],比较2组心电图疗效及不良反应。结果:治疗后,2组室性早搏发生次数均减少,ST段下移幅度、SDNN和RMSSD均减少(P<0.05),且联合组少于对照组(P<0.05)。联合组心电图总有效率89.47%,高于对照组66.67%(P<0.05)。治疗后,2组GMP-140水平均降低(P<0.05),且联合组低于对照组(P<0.05)。治疗后,2组NO、VEGF水平均升高(P<0.05),且联合组高于对照组(P<0.05),2组ET水平均降低(P<0.05),且联合组低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血栓通注射液联合常规西药治疗稳定型冠心病心绞痛心血瘀阻证患者,可改善心电图指标,降低GMP-140水平,调节血管内皮功能,且安全性良好。
Objective:To observe the clinical effect of Xueshuantong Injection combined with routine western medicine for stable angina pectoris due to coronary heart disease with heart blood stasis obstruction syndrome.Methods:A total of 114 cases of patients with stable angina pectoris due to coronary heart disease with heart blood stasis obstruction syndrome were selected as the study objects and divided into the control group and the combination group according to the random number table method,with 57 cases in each group.The control group was treated with routine western medicine,and the combination group was treated with Xueshuantong Injection combined with routine western medicine.The 24-hour dynamic electrocardiogram[the frequency of ventricular premature beats,the extent of ST segment depression,the standard deviation of R-R intervals(SDNN),the root mean square of successive R-R interval differences(RMSSD)],vascular endothelial function indicators[nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin(ET)],and platelet activation function indicators[platelet membrane protein-140(GMP-140)]were compared between the two groups before and after treatment.Curative effects of electrocardiogram and adverse reactions were compared between the two groups.Results:After treatment,the frequency of ventricular premature beats,the extent of ST segment depression,SDNN,and RMSSD in the two groups were decreased(P<0.05),and the above indexes in the combination group were lower than those in the control group(P<0.05).The total effective rate of electrocardiogram was 89.47%in the combination group,higher than that of 66.67%in the control group(P<0.05).After treatment,the GMP-140 levels in the two groups were decreased(P<0.05),and the level in the combination group was lower than that in the control group(P<0.05).After treatment,the levels of NO and VEGF in the two groups were increased(P<0.05),and the levels in the combination group were higher than those in the control group(P<0.05);the ET levels in the two groups were decreased(P<0.05),and the ET level in the combination group was lower than that in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For patients with stable angina pectoris due to coronary heart disease with heart blood stasis obstruction syndrome,Xueshuantong Injection combined with routine western medicine can improve electrocardiogram indicators,reduce the level of GMP-140,and regulate vascular endothelial function with good safety.
作者
孔双燕
苏运璞
史少博
KONG Shuangyan;SU Yunpu;SHI Shaobo(Pingdingshan First People's Hospital,Pingdingshan Henan 467000,China)
出处
《新中医》
CAS
2023年第21期29-33,共5页
New Chinese Medicine
关键词
稳定型冠心病心绞痛
心血瘀阻证
血栓通注射液
24
h动态心电图
血小板活化功能
血管内皮功能
Stable angina pectoris due to coronary heart disease
Heart blood stasis obstruction syndrome
Xueshuantong Injection
24-hour dynamic electrocardiogram
Platelet activation function
Vascular endothelial function
作者简介
孔双燕(1984-),女,主治医师,E-mail:ex962oz5742@163.com。
