摘要
目的:评价白头翁汤灌肠辅助治疗溃疡性结肠炎(UC)的有效性及安全性。方法:检索中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库(VIP)、万方数据库、临床试验注册登记库、PubMed、Embase等,筛选随机对照试验研究,采用RevMan 5.3软件对结局指标数据进行Meta分析。结果:最终筛选14项研究,Meta分析结果显示:总有效率[RR=1.21,95%CI=(1.15,1.28),P<0.01];不良反应发生率[RR=0.50,95%CI=(0.27,0.92),P<0.01];腹痛积分[SMD=-1.05,95%CI=(-1.48,-0.62),P<0.01];腹泻积分[SMD=-1.32,95%CI=(-2.00,-0.65),P<0.01];里急后重积分[SMD=-2.95,95%CI=(-4.60,-1.29),P<0.01];脓血便积分[SMD=-1.91,95%CI=(-2.99,-0.83),P<0.01];Mayo评分[MD=-1.22<95,95%CI=(-1.85,-0.59),P<0.001];Baron评分[MD=-0.30,95%CI=(-0.45,-0.16),P<0.01];IL-10水平[SMD=1.17,95%CI=(0.90,1.43),P<0.01];TNF-α水平[SMD=-2.20,95%CI=(-3.48,-0.92),P<0.001];TNF-β水平[SMD=-1.54,95%CI=(-1.89,-1.18),P<0.01]。结论:白头翁汤灌肠治疗UC可以提升治疗总效果,缓解UC患者的腹痛、腹泻及脓血便等症状,并具有抑制肠道炎症反应,促进肠道黏膜损伤愈合的作用,具有更低的不良反应发生率,安全性较高,值得临床推广。
Objective To evaluate the efficacy and safety of Baitouweng decoction enema in the adjuvant treatment of ulcerative colitis(UC).Methods Randomized controlled trials were searched in China Academic Journal Full-text Database(CNKI),China Biomedical Literature Database(CBM),VIP database,Wanfang database,clinical trial registry,PubMed,Embase etc.The Meta-analysis of outcome index data was performed using RevMan 5.3 software.Results Fourteen studies were selected,and the results of Meta-analysis showed that the total response rates were as follows[RR=1.21,95%CI=(1.15,1.28),P<0.01].Incidence of adverse reactions[RR=0.50,95%CI=(0.27,0.92),P<0.01];Abdominal pain score[SMD=-1.05,95%CI=(-1.48,-0.62),P<0.01];Diarrhea score comparison[SMD=-1.32,95%CI=(-2.00,-0.65),P<0.01];[SMD=-2.95,95%CI=(-4.60,-1.29),P<0.01];Abscess,blood and stool score:[SMD=-1.91,95%CI=(-2.99,-0.83),P<0.01];Mayo score:[MD=-1.22<95,95%CI=(-1.85,-0.59),P<0.001];Comparison of Baron scores[MD=-0.30,95%CI=(-0.45,-0.16),P<0.01];Level of IL-10 SMD=1.17,95%CI=(0.90,1.43),P<0.01;TNF-αlevel[SMD=-2.20,95%CI=(-3.48,-0.92),P<0.001];TNF-βlevel[SMD=-1.54,95%CI=(-1.89,-1.18),P<0.01].Conclusion The enema with Baitouweng decoction can improve the total therapeutic effect,relieve the symptoms of abdominal pain,diarrhea and purulent bloody stool in UC patients,inhibit intestinal inflammatory reaction and promote the healing of intestinal mucosal injury,with lower adverse reaction rate and higher safety which is worthy of clinical promotion.
作者
张聪伟
刘金响
吕小龙
杜晓泉
樊振
李龙梅
ZHANG Cong-wei;LIU Jin-xiang;LYU Xiao-long(Department of the Second Gastroenterology,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《中国中西医结合外科杂志》
CAS
2023年第6期758-765,共8页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家自然科学基金青年基金项目(81803951)
陕西省科技厅课题(2022JM-506)
陕西中医药大学校级课题(2021GP44)
陕西省第3届名中医杜晓泉工作传承工作室建设项目(2019021)。
作者简介
通信作者:吕小龙,E-mail:1142585336@qq.com。
