摘要
目的:探讨乳腺癌(BC)组织中雄激素受体(AR)、叉头框蛋白A1(FOXA1)表达与临床病理特征的关系。方法:收集德州市第二人民医院2022年5月至2022年11月手术切除的120例乳腺癌标本,采用免疫组织化学方法检测AR、FOXA1的表达情况,采用χ^(2)检验分析AR、FOXA1的表达与临床病理特征的关系。结果:AR、FOXA1在乳腺癌组织、癌旁组织和良性乳腺肿瘤组织中的表达差异有统计学意义(χ^(2)=15.442、11.011,均P<0.005);AR、FOXA1的表达与组织分级(χ^(2)=25.424、15.130,均P<0.005)、组织是否存在坏死(χ^(2)=4.320、6.430,均P<0.05)、分子分型(χ^(2)=25.998、16.680,均P<0.005)、雌激素受体(ER)(χ^(2)=26.619、17.761,均P<0.001)、PR(χ^(2)=17.531、5.607,均P<0.005)、Ki67(χ^(2)=16.954、10.606,均P<0.005)的表达相关;AR、FOXA1的表达与组织分级(rs=0.453、0.349,均P<0.001)、分子分型(rs=0.405、0.323,均P<0.001)、ER(rs=0.471、0.385,均P<0.001)、PR(rs=0.382、0.261,均P<0.005)、Ki67(rs=0.376、0.297,均P<0.005)的表达呈正相关,与组织坏死(rs=-0.190、-0.231,均P<0.05)呈负相关。结论:AR、FOXA1的表达与乳腺癌患者的组织分级、组织坏死以及分子分型等临床病理参数具有相关性。
Objective:To study the correlation between the expression of androgen receptor(AR)and forkhead box protein A1(FOXA1)and clinicopathological parameters in breast cancer(BC)tissues.Methods:The clinicopathological data of 120 breast cancer patientswere collected from May 2022 to November 2022 in the Second People Hospital of Dezhou.The expressions of AR and FOXA1 in patients were determined by immunohistochemistry.The correlation between the expression of AR,FOXA1 and clinicopathological parameters in patients with breast cancer was analyzed byχ^(2) test.Results:The expressions of AR and FOXA1 in breast cancer tissue,paracancer tissue and benign breast tumor tissue were significantly different(χ^(2)=15.442,11.011,both P<0.005).The expression of AR and FOXA1 was correlated with histological grade(χ^(2)=25.424,15.130,both P<0.005),tumor necrosis(χ^(2)=4.320,6.430,both P<0.05),molecular typing(χ^(2)=25.998,16.680,both P<0.005),ER(χ^(2)=26.619,17.761,both P<0.001),PR(χ^(2)=17.531,5.607,both P<0.005)and Ki67 expression(χ^(2)=16.954,10.606,both P<0.005).The expression of AR and FOXA1 was positively correlated with histological grade(rs=0.453,0.349,both P<0.001),molecular typing(rs=0.405,0.323,both P<0.001),ER(rs=0.471,0.385,both P<0.001),PR(rs=0.382,0.261,both P<0.05)and Ki67 expression(rs=0.376,0.297,both P<0.005).The expression of AR and FOXA1 was negatively correlated with tumor necrosis(rs=-0.190,-0.231,both P<0.05).Conclusion:The expression of AR and FOXA1 has a correlation with the clinicopathological parameters such as histological grade,tumor necrosis and molecular typing of breast cancer patients.
作者
丁新新
李华芳
张丽伟
滕敏敏
张素玲
DING Xin-xin;LI Hua-fang;ZHANG Li-wei;TENG Min-min;ZHANG Su-ling(Department of Pathology,The Second People Hospital of Dezhou,Dezhou 253004,China;Medical Imaging Center,The Second People Hospital of Dezhou,Dezhou 253004,China;Breast Surgery Clinic,The Second People Hospital of Dezhou,Dezhou 253004,China)
出处
《天津医科大学学报》
2023年第6期588-593,共6页
Journal of Tianjin Medical University
基金
山东省医药卫生科技发展计划(2019WS012)。
关键词
乳腺癌
雄激素受体
叉头框蛋白A1
breast cancer
androgen receptor
forkhead box protein A1
作者简介
丁新新(1992-),女,主管技师,硕士,研究方向:病理技术;通信作者:张素玲,E-mail:1054594352@qq.com。
