摘要
肝癌是常见的、致死率高的恶性肿瘤之一。在世界范围内发病率一直居高不下。目前,肝癌缺乏有效的治疗手段,化疗和靶向药物治疗仍占主要地位。然而,传统药物在肿瘤组织浓度低或滞留时间短,难以发挥高效治疗作用。纳米技术作为一种提高疗效降低毒性的方法在肿瘤治疗领域得到了广泛的应用,尤其是基于肿瘤微环境特点开发的纳米递药系统已经成为肿瘤治疗领域的主力军。肝癌具有低pH、低氧、血供丰富、酶过表达、氧化还原水平高、免疫抑制强等特点,为构建多功能协同的纳米递药系统对抗肝癌提供了靶点。因此,笔者针对目前基于响应和调控肝癌微环境开发的纳米递药系统在肝癌治疗中的应用与进展进行综述,通过对比微环境和纳米递药系统对肝癌治疗的影响,为后续构建更具针对性的纳米递药系统治疗肝癌提供借鉴。
Liver cancer is one of the malignant tumors with high mortality,whose incidence remains high all over the world.The current treatment of liver cancer is mainly based on traditional chemo-and targeted drug therapy.Though,for the vast majority of patients with primary liver cancer,there is no effective clinical treatment,and the prognosis is poor.Nanotechnology has been widely used in the field of tumor therapy as a method to improve efficacy and reduce toxicity.In particular,nano-drug delivery systems developed based on the characteristics of tumor microenvironment have become a research hotspot in tumor therapy.The liver cancer microenvironment have characteristics of low pH,low oxygen,abundant blood supply,enzyme overexpression,high redox level,and strong immunosuppression,which can be used as research targets to design nano-drug delivery systems.Therefore,the purpose of this paper is to review the current application and progress of nano-drug delivery systems developed based on the response and regulation of the liver cancer microenvironment in the treatment of liver cancer,and to compare the effects of the microenvironment and the nano-drug delivery system,and provide a reference for building more advanced nano-drug delivery systems.
作者
路诗佳
李国飞
LU Shi-jia;LI Guo-fei(Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2023年第16期1447-1456,共10页
Chinese Pharmaceutical Journal
关键词
肝癌
肝癌微环境
纳米递药系统
刺激响应
免疫抑制调控
liver cancer
liver cancer microenvironment
nano-drug delivery system
stimulation response
immunosuppressive regulation
作者简介
路诗佳,女,硕士研究生研究方向:基于肝癌微环境开发的纳米递药系统的研究;通讯作者:李国飞,男,副教授,副主任药师,硕士生导师研究方向:肿瘤及炎症靶向制剂相关研究,Tel:(024)96615-71111。
