摘要
目的探析血栓通配合吡拉西坦治疗急性脑梗死患者的效果。方法选取2020年1月—2023年1月苏州市相城人民医院收治的急性脑梗死患者66例,依据随机数字表法分2组,每组33例。对照组采用吡拉西坦治疗,观察组加之血栓通治疗。比较两组临床疗效、脑血流动力学指标、NIHSS及FIM评分。结果观察组临床有效率96.97%高于对照组的78.79%,组间差异有统计学意义(P<0.05),治疗前两组脑血流动力学指标比较差异无统计学意义(P>0.05),观察组治疗后Vm[(58.79±4.21)cm/s]、Vd[(52.45±4.08)cm/s]、Vp[(66.45±5.02)cm/s]水平高于对照组,组间差异具有统计学意义(P<0.05),治疗后观察组PT[(12.63±0.35)s]、APTT[(31.27±1.94)s]水平高于对照组,NSE(6.41±1.92)μg/L、MBP[(10.08±3.17)μg/L]、S100B[(0.97±0.07)ng/L]、D-二聚体[(0.36±0.03)mg/L]水平低于对照组,两组比较差异具有统计学意义(P<0.05),治疗前两组NIHSS评分和FIM评分比较差异无统计学意义(P>0.05),治疗后观察组NIHSS评分[(9.45±1.21)分]低于对照组[(13.18±1.25)分],FIM评分[(104.65±5.42)分]高于对照组[(98.42±5.21)分],组间差异具有统计学意义(P<0.05)。结论急性脑梗死患者采用血栓通联合吡拉西坦治疗效果明显,患者脑血流动力学指标明显升高,其神经功能、日常生活活动能力有所改善,临床上可借鉴及推广。
Objective To explore the effect of Xueshuantong combined with piracetam on patients with acute cerebral infarction.Methods From January 2020 to January 2023,66 patients with acute cerebral infarction admitted to Xiangcheng People's Hospital were enrolled for the study and divided into two groups with 33 cases/group according to random number table method.The control group was treated with Piracetam,and the observation group was treated with Xueshuantong.The clinical efficacy,cerebral hemodynamic indexes,NIHSS and FIM scores were compared between the two groups.Results The clinical effective rate of the observation group was 96.97%higher than that of the control group(78.79%),and there was a significant difference between the two groups(P<0.05).There was no difference in cerebral hemodynamic indexes between the two groups before treatment(P>0.05).After treatment,Vm[(58.79±4.21)cm/s],Vd[(52.45±4.08)cm/s]and Vp[(66.45±5.02)cm/s]in observation group were higher than those in control group,and the difference between groups was significant(P<0.05).After treatment,PT[(12.63±0.35)s]and APTT[(31.27±1.94)s]in observation group were higher than those in control group.The levels of NSE[(6.41±1.92)μg/L],MBP[(10.08±3.17)μg/L],S100B[(0.97±0.07)ng/L],D-dimer[(0.36±0.03)mg/L]were lower than those of control group,and there were significant differences between the two groups(P<0.05).There was no difference in NIHSS score and FIM score between the two groups before treatment(P>0.05).After treatment,NIHSS score of the observation group[(9.45±1.21)]was lower than that of the control group[(13.18±1.25)],and FIM score of the observation group[(104.65±5.42)]was higher than that of the control group[(98.42±5.21)].The difference between groups was significant(P<0.05).Conclusion Xueshuantong combined with Piracetam has obvious effect in the treatment of acute cerebral infarction patients.The cerebral hemodynamic indexes of patients are significantly increased,and the neurological function and ability of daily living activities are improved,which can be used for reference and promotion in clinical practice.
作者
方兰
苏静霞
浦莉婷
FANG Lan;SU Jing-xia;PU Li-ting(Department of Neurology,Xiangcheng People's Hospital,Suzhou,Jiangsu,215124,China;Department of Geriatrics,Xiangcheng People's Hospital,Suzhou,Jiangsu,215124,China)
出处
《中国血液流变学杂志》
CAS
2023年第2期186-190,共5页
Chinese Journal of Hemorheology
作者简介
方兰(1983-),女,江苏苏州人,学士,副主任医师,研究方向:脑血管病及周围神经病;通讯作者:苏静霞,E-mail:12523049@qq.com。
