摘要
N6-甲基腺嘌呤修饰(N6-methyladenosine,m6A)是在真核细胞中最广泛的RNA修饰,属于表观遗传学修饰的一种,参与多种肿瘤的发生发展。胃癌是全球癌症死亡率排名第三的恶性肿瘤,目前对于胃癌的发生发展机制了解不完全,早期胃癌难发现,进展期胃癌手术机会少且药物治疗效果欠佳。而在胃癌中,m6A修饰相关因子表达异常,引发了m6A修饰失调,进而影响到胃癌的进展,这也提示我们m6A修饰相关因子有作为胃癌治疗靶点或诊断标志物的潜力。因此,本文就m6A修饰在胃癌发生发展过程中的作用以及可能涉及到的治疗方法予以综述。
N6-methyladenosine(m6A)is the most widespread RNA modification in eukaryotic cells,which is a type of epigenetic modification and is involved in multiple tumors occurrence and development.Gastric cancer is the third most deadly malignant tumor in the world.At present,the mechanism of occurrence and development of gastric cancer is not fully understood,early gastric cancer is difficult to detect,and there are few surgery opportunities for advanced gastric cancer and poor drug therapy.In gastric cancer,the expression of m6A modification-related factors is abnormal,causing m6A modification disorders,which in turn affects the progression of gastric cancer.It also suggests that m6A-related regulators have the potential to be used as therapeutic targets or diagnostic markers for gastric cancer.Thus,this review will focus on the mechanism of m6A modification in the occurrence and development of gastric cancer and the treatment methods that may be involved.
作者
徐昊志
尹昆
杨景玉
XU Haozhi;YIN Kun;YANG Jingyu(Digestive Diseases Hospital of Shandong First Medical University,Shandong Institute of Parasitic Diseases,Shandong Jining 272033,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第20期3896-3900,共5页
Journal of Modern Oncology
基金
山东省医药卫生科技发展计划项目(编号:202003030503)
山东省泰山学者工程项目(编号:tsqn202103186)
山东省医学科学院医药卫生科技创新工程
山东第一医科大学学术提升计划项目(编号:2019QL005)。
作者简介
徐昊志(1997-),男,山东泰安人,硕士研究生在读,主要从事m6A甲基化在胃癌中的作用及应用研究。E-mail:316676440@qq.com;通信作者:杨景玉(1964-),男,山东济宁人,主任医师,硕士生导师,主要从事消化系统疾病的防治与早癌筛查工作。
