摘要
目的探讨消化性溃疡(PU)患者幽门螺杆菌(Hp)感染与胃蛋白酶原的关系。方法选取2016年6月—2022年6月于安徽省安庆市立医院消化科就诊后确诊为Hp感染阳性的PU患者123例作为阳性组,Hp感染阴性的PU患者115例作为阴性组,并选取同期因参与胃癌筛查项目需作胃镜检查及病理组织活检的健康个体112例作为对照组。比较3组研究对象血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及PGR(PGⅠ/PGⅡ)水平;比较Hp阳性组与阴性组不同溃疡类型患者血清PGⅠ、PGⅡ水平;分析PU患者PGⅠ、PGⅡ水平与Hp感染阳性的相关性;比较不同溃疡类型PU患者治疗前及治疗后4周血清PGⅠ、PGⅡ水平。结果阴性组和阳性组患者治疗前血清PGⅠ、PGⅡ水平均高于对照组,PGR均小于对照组,差异均有统计学意义(P<0.05);阳性组患者治疗前血清PGⅠ、PGⅡ水平均高于阴性组,PGR小于阴性组,差异均有统计学意义(P<0.05)。阳性组不同溃疡类型患者治疗前血清PGⅠ、PGⅡ水平均高于阴性组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,PGⅠ、PGⅡ水平与Hp感染呈正相关(r=0.256、0.419,均P<0.05)。胃溃疡与十二指肠溃疡患者治疗前血清PGⅠ、PGⅡ水平及PGR比较,差异均无统计学意义(P>0.05);胃溃疡与十二指肠溃疡患者治疗后血清PGⅠ、PGⅡ水平均低于治疗前,而PGR均大于治疗前,差异均有统计学意义(P<0.05)。结论PU患者Hp感染与胃蛋白酶指标水平变化有关,Hp感染呈阳性时胃蛋白酶指标水平随之升高。通过检测PU患者血清PGⅠ、PGⅡ水平,可为临床诊治PU患者提供一定参考。
Objective This paper aims to investigate the relationship between Helicobacter pylori(Hp)infection factors and pepsinogen in patients with peptic ulcers(PU).Methods From June 2016 to June 2022,123 PU patients with positive Hp infection and 115 PU patients with negative Hp infection were selected as the positive group and negative group,respectively.Additionally,112 healthy individuals who required gastroscopy and pathological biopsy due to participating in the gastric cancer screening program in the same period were selected as the control group.The levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and pepsinogenⅠ/Ⅱratio(PGⅠ/PGⅡ)were compared among the three groups.The levels of PGⅠand PGⅡwere compared between the positive group and the negative group in patients with different ulcer types.The correlation between the levels of PGⅠand PGⅡand the positive rate of Hp infection in patients with PU was analyzed.The levels of PGⅠand PGⅡwere compared before treatment and 4 weeks after treatment in PU patients with different ulcer types.Results The levels of PGⅠand PGⅡin the negative and positive groups were higher than those in the control group,and PGR was lower than that in the control group,with statistical significance(P<0.05).The levels of PGⅠand PGⅡin the positive group were higher than those in the negative group,and PGR was lower than that in the negative group,with statistical significance(P<0.05).The levels of PGⅠand PGⅡin patients with different ulcer types in the positive group were significantly higher than those in the negative group(P<0.05).Pearson correlation analysis showed that PGⅠand PGⅡlevels were positively correlated with positive Hp infection(r=0.256,0.419,both P<0.05).No significant difference was found in PGⅠ,PGⅡlevels and PGR before treatment among patients with gastric and duodenal ulcers(P>0.05).PGⅠand PGⅡlevels after treatment in patients with gastric and duodenal ulcers were lower than those before treatment,while PGR was greater than that before treatment,with statistical significance(P<0.05).Conclusion The Hp infection is correlated with the level of pepsin in patients with PU,and the level of pepsin increases under the circumstances of positive Hp infection.The detection of PGⅠand PGⅡlevels in patients with PU can provide evidence for clinical diagnosis and treatment of this population.
作者
鲁树华
吴夏琴
卢建辉
Lu Shuhua;Wu Xiaqin;Lu Jianhui(Department of Nuclear Medicine,Anqing Medical Center of Anhui Medical University/Anqing Municipal Hospital,Anqing Anhui 246001,China;Department of Clinical Laboratory,Anqing Medical Center of Anhui Medical University/Anqing Municipal Hospital,Anqing Anhui 246001,China)
出处
《保健医学研究与实践》
2023年第7期36-39,共4页
Health Medicine Research and Practice
基金
安徽省自然科学基金项目(1708085QH213)。
作者简介
第一作者:鲁树华,E-mail:lsh13866066046@163.com。
