摘要
目的探讨组蛋白去乙酰化酶3(HDAC3)、热休克蛋白90(HSP90)对急性心肌梗死(AMI)患者心室重构及预后的评估价值。方法选取2021年1月至2022年6月北京市昌平区中西医结合医院收治的128例AMI患者为研究组,记录患者经皮冠状动脉介入(PCI)术后6个月内发生的不良心血管事件,根据结果将患者分为预后不良组(n=33),预后良好组(n=95)。同期选择年龄、性别相仿的110例健康体检志愿者为对照组。采用酶联免疫法(ELISA)检测血清中HDAC3、HSP90的表达水平,超声心动图检测心室重构参数。Pearson法分析AMI患者血清中HDAC3、HSP90与心室重构指标的相关性;受试者工作特征(ROC)曲线分析HDAC3、HSP90水平对AMI患者预后不良的评估价值。结果与对照组相比,研究组患者血清中HDAC3、HSP90水平均升高,差异有统计学意义(P<0.05);研究组患者左心室舒张末期内径(LVEDD)、左心房内径(LAD)、左心室后壁厚度(LVPWT)、左心室后壁舒张末期厚度(PWD)、左心室后壁收缩末期厚度(PWS)、左心室心肌质量指数(LVMI)均大于对照组(P均<0.05),左心室射血分数(LVEF)低于对照组(P<0.05);血清HDAC3、HSP90水平与LVEDD、LAD、LVPWT、PWD、PWS、LVMI呈正相关(P均<0.05),与LVEF呈负相关(P<0.05);ROC曲线结果显示,血清HDAC3、HSP90水平预测AMI患者预后不良的曲线下面积(AUC)分别为0.858、0.864,二者联合预测的AUC为0.947,高于单一指标检测。结论HDAC3、HSP90在AMI患者血清中均呈高水平,早期检测二者可作为评估AMI患者心室重构及预后不良的血清标志物。
Objective To explore the value of histone deacetylase 3(HDAC3)and heat shock protein 90(HSP90)in evaluating ventricular remodeling and prognosis in patients with acute myocardial infarction(AMI).Methods A total of 128 patients with AMI admitted to changping district integrated traditional chinese and western medicine hospital of beijing from January 2021 to June 2022 were regarded as the study group,adverse cardiovascular events occurred within 6 months after percutaneous coronary intervention(PCI)were recorded,according to the results,the patients were grouped into poor prognosis group(n=33)and good prognosis group(n=95).Meantime,110 healthy volunteers of similar age and sex were regarded as the control group.The expression levels of HDAC3 and HSP90 in serum were detected by enzyme-linked immunosorbent assay(ELISA),and ventricular remodeling parameters was measured by echocardiography.Pearson method was applied to analyze the correlation between serum HDAC3,HSP90 and ventricular remodeling index in patients with AMI;receiver operating characteristic(ROC)curve was applied to analyze the evaluation value of HDAC3 and HSP90 levels on the poor prognosis of patients with AMI.Results Compared with the control group,the serum levels of HDAC3 and HSP90 in the study group were obviously higher(P<0.05);the left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),left ventricular posterior wall thickness(LVPWT),left ventricular posterior wall end-diastolic thickness(PWD),left ventricular posterior wall end-systolic thickness(PWS),left ventricular myocardial mass index(LVMI)in the study group were higher than those in the control group(P<0.05),and left ventricular ejection fraction(LVEF)was lower than that in the control group(P<0.05);the serum levels of HDAC3 and HSP90 were positively correlated with LVEDD,LAD,LVPWT,PWD,PWS and LVMI(P<0.05),and negatively correlated with LVEF(P<0.05);ROC curve results showed that the area under the curve(AUC)of serum HDAC3 and HSP90 levels in predicting poor prognosis in patients with AMI was 0.858 and 0.864,respectively,and the AUC predicted by the combination of the two was 0.947,which was higher than the single indicator detection.Conclusion HDAC3 and HSP90 are both high in the serum of AMI patients.Early detection of HDAC3 and HSP90 can be used as serum markers to evaluate ventricular remodeling and poor prognosis in AMI patients.
作者
郝静宇
王金萍
管斌斌
付婧婷
HAO Jing-yu;WANG Jin-ping;GUAN Bin-bin;FU Jing-ting(Department of Cardiology,Changping District Integrated Traditional and Western Medicine Hospital,Beijing 102208,China)
出处
《中国心血管病研究》
CAS
2023年第9期853-857,共5页
Chinese Journal of Cardiovascular Research
关键词
急性心肌梗死
心室重构
蛋白去乙酰化酶3
热休克蛋白90
预后
Acute myocardial infarction
Ventricular remodeling
Histone deacetylase 3
Heat shock protein 90
Prognosis
