摘要
目的:探讨癌胚抗原相关黏附分子1(CEACAM1)、成纤维细胞生长因子23(FGF-23)、微小RNA-499(miR-499)在急性心肌梗死(AMI)中的表达及其与冠状动脉狭窄程度的相关性。方法:选取2019年2月-2021年2月天水市第一人民医院收治的80例AMI患者。另外选同期60例体检健康者作为对照组。将80例AMI患者根据冠状动脉血管计分段标准分为血管轻度狭窄组(1~30分,27例)、血管中度狭窄组(31~60分,39例)、血管重度狭窄组(>60分,14例)。检测所有纳入对象的CEACAM1、FGF-23、miR-499水平。随访AMI患者6个月,依据随访是否发生不良心血管事件,分为预后不良组与预后良好组。比较四组CEACAM1、FGF-23、miR-499水平,比较预后不良组与预后良好组CEACAM1、FGF-23、miR-499水平,分析CEACAM1、FGF-23、miR-499水平对冠状动脉狭窄程度的诊断价值。分析CEACAM1、FGF-23、miR-499水平与冠状动脉狭窄程度的相关性。结果:血管轻度、中度、重度狭窄组CEACAM1、FGF-23、miR-499水平均明显高于对照组(P<0.05)。预后不良组CEACAM1、FGF-23、miR-499水平均明显高于预后良好组(P<0.05)。ROC曲线分析显示,血清CEACAM1、FGF-23、miR-499水平对于判定冠状动脉狭窄程度具有诊断价值(AUC=0.921、0.937、0.924,P<0.05)。CEACAM1、FGF-23、miR-499与冠状动脉狭窄程度均呈正相关(P<0.01)。结论:AMI患者CEACAM1、FGF-23、miR-499水平均有明显异常,各指标与患者预后有关,可用于AMI诊断及预后评估。
Objective:To investigate the expression of carcino-embryonic antigen related cellular adhesion molecule 1 (CEACAM1),fibroblast growth factor 23 (FGF-23) and microRNA-499 (miR-499) in acute myocardial infarction (AMI) and its correlation with degree of coronary artery stenosis.Method:A total of 80 AMI patients admitted to the First People’s Hospital of Tianshui City from February 2019 to February 2021 were selected.Sixty healthy subjects at the same time were selected as the control group.80 patients with AMI were divided into mild vascular stenosis group (1-30 points,27 cases),moderate vascular stenosis group (31-60 points,39 cases) and severe vascular stenosis group (>60 points,14 cases) according to the sectional standard of coronary artery scoring.The CEACAM1,FGF-23 and miR-499 levels of all included subjects were detected.AMI patients were followed up for 6 months,and they were divided into poor prognosis group and good prognosis group according to whether adverse cardiovascular events occurred during follow-up.The levels of CEACAM1,FGF-23 and miR-499 in the four groups were compared,and the levels of CEACAM1,FGF-23 and miR-499 in the poor prognosis group and the good prognosis group were compared,the diagnostic values of CEACAM1,FGF-23 and miR-499 in severe coronary artery stenosis were analyzed.The correlation among CEACAM1,FGF-23,and miR-499 levels and coronary artery stenosis degree was analyzed.Result:The levels of CEACAM1,FGF-23,and miR-499 in vessels with mild,moderate,and severe stenosis group were significantly higher than those in control group (P<0.05).The levels of CEACAM1,FGF-23,and miR-499 in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).ROC curve analysis showed that the levels of serum CEACAM1,FGF-23 and miR-499 had diagnostic value in judging the degree of coronary artery stenosis (AUC=0.921,0.937,0.924,P<0.05).There were positive correlations between CEACAM1,FGF-23,and miR-499 with coronary artery stenosis degree (P<0.01).Conclusion:The levels of CEACAM1,FGF-23 and miR-499 in patients with AMI are obviously abnormal.Each index is related to the prognosis of patients,and can be used for the diagnosis and prognosis evaluation of AMI.
作者
马亚鹏
方万春
MA Yapeng;FANG Wanchun(The First People’s Hospital of Tianshui City,Tianshui 741000,China;不详)
出处
《中外医学研究》
2022年第19期60-64,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
甘肃省天水市科技支撑计划项目(2020-SHFZKJK-8636)。
