摘要
目的构建鉴别诊断子宫内膜异位症相关性卵巢癌(EAOC)的列线图。方法选择2005年1月至2021年12月于郑州大学第三附属医院确诊为卵巢透明细胞癌及卵巢子宫内膜样腺癌的患者90例,将其分为EAOC组(23例)及non-EAOC组(67例),比较两组患者的临床及病理特征差异。结果多因素logistic回归分析显示绝经状态、合并子宫良性病变、痛经或不规则出血、ROMA指数与EAOC显著相关;列线图显示上述指标联合诊断EAOC性能较高(AUC=0.896,P<0.05),决策曲线分析衡量模型临床效用较佳。结论EAOC患者分期较早,多预后较佳,具有独特的临床表现,临床上应提高对EAOC的鉴别意识并根据其特点指导临床诊治。
Objective To construct a nomogram for differential diagnosis of endometriosis-associated ovarian cancer(EAOC).Methods A total of 90 patients diagnosed with ovarian clear cell carcinoma and ovarian endometrioid carcinoma in the Third Affiliated Hospital of Zhengzhou University from January 2005 to December 2021 were selected and divided into EAOC group(23 cases)and non-EAOC group(67 cases).The clinical and pathological characteristics of the two groups were compared.Results Multivariate logistic regression analysis showed that menopause,combination with benign uterine lesions,dysmenorrhea or irregular bleeding and ROMA index were significantly correlated with EAOC.Nomogram showed high performance of the combined index in diagnosing EAOC(AUC=0.898,P<0.05),and the clinical efficacy of the model was better measured by decision curve analysis.Conclusion EAOC patients have early stages,better prognosis,and unique clinical manifestations.It is necessary to improve the awareness of EAOC identification and give clinical guidance according to its characteristics.
作者
王媛媛
李颖颖
马克青
高雅
常丰华
封全灵
WANG Yuanyuan;LI Yingying;MA Keqing;GAO Ya;CHANG Fenghua;FENG Quanling(Department of Gynecology,Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《空军军医大学学报》
CAS
2023年第9期881-884,889,共5页
Journal of Air Force Medical University
基金
河南省高等学校重点科研项目(20B320055)。
关键词
子宫内膜异位症
恶变
卵巢癌
临床特征
列线图
endometriosis
malignant transformation
ovarian cancer
clinical features
nomogram
作者简介
王媛媛,硕士研究生,从事妇产科学研究,Tel:15615882976,E-mail:15615882976@163.com;通信作者:封全灵,Tel:19513363784,E-mail:bz19513363784@163.com。
