摘要
目的探讨组织Wnt/β-catenin信号通路蛋白表达水平与卵巢子宫内膜异位症(OE)组织恶变的关系。方法选取2016年10月至2018年10月在郑州人民医院就诊的46例子宫内膜异位症相关性卵巢癌(EAOC,即OE恶变)患者为EAOC组,另取同期入院的34例OE患者为OE组,采用免疫组化法检测两组患者组织中β-catenin和基质金属蛋白酶-9(MMP-9)表达水平,分析组织中β-catenin和MMP-9表达水平与临床病理特征的关系以及与预后的关系。结果EAOC组β-catenin阳性表达率为63.04%,高于OE组的23.53%,MMP-9阳性表达率为69.57%,高于OE组的44.12%(P<0.05);β-catenin的阳性表达率在不同分化程度、淋巴结转移、临床分期、铂敏感性的EAOC组织中比较,差异具有统计学意义(P<0.05);MMP-9的阳性表达率在不同分化程度、淋巴结转移、临床分期EAOC组织中比较,差异具有统计学意义(P<0.05);β-catenin阴、阳性患者3年生存率分别是68.97%(20/29)、35.29%(6/17),差异有统计学意义(χ^(2)=4.945,P=0.026),MMP-9阴、阳性患者3年生存率分别是68.75%(22/32)、28.57%(4/14),差异有统计学意义(χ^(2)=6.398,P=0.011)。结论Wnt/β-catenin信号通路可能是OE恶变的重要途径,其中,β-catenin和MMP-9均与OE恶变密切相关,这两个指标的阳性表达可以提示EAOC患者预后不良。
Objective To explore the relationship between Wnt/β-catenin signaling pathway proteins and malignant transformation of ovarian endometriosis(OE)tissues.Methods A total of 46 patients with endometriosis-associated ovarian cancer(EAOC,malignant transformation of OE)treated in the hospital were enrolled as EAOC group between October 2016 and October 2018,while 34 patients with OE during the same period were enrolled as OE group.The expression levels ofβ-catenin and matrix metalloproteinase-9(MMP-9)were detected by immunohistochemistry,and their relationship with clinicopathological characteristics and prognosis was analyzed.Results The positive expression rate ofβ-catenin in EAOC group was higher than that in OE group(63.04%vs 23.53%),and positive expression rate of MMP-9 was higher than that in OE group(69.57%vs 44.12%,P<0.05).There were significant differences in positive expression rate ofβ-catenin among EAOC patients with different differentiation degree,lymph node metastasis,clinical staging and platinum-sensitivity(P<0.05).There were significant differences in positive expression of MMP-9 among EAOC patients with different differentiation degree,lymph node metastasis and clinical staging(P<0.05).The differences in 3-year survival rate between patients withβ-catenin negative and positive were statistically significant[68.97%(20/29)vs 35.29%(6/17)](χ^(2)=4.945,P=0.026).The differences in 3-year survival rate between patients with MMP-9 negative and positive were statistically significant[68.75%(22/32)vs 28.57%(4/14)](χ^(2)=6.398,P=0.011).Conclusion Wnt/β-catenin signaling pathways may be important ways of OE malignant transformation.Bothβ-catenin and MMP-9 are closely related to malignant transformation of OE,and their positive expressions can indicate poor prognosis in EAOC patients.
作者
田金
张喜红
宋晓霞
郑岩
马莉
TIAN Jin;ZHANG Xihong;SONG Xiaoxia;ZHENG Yan;MA Li(Zhengzhou People's Hospital,Zhengzhou 450053,China)
出处
《中国实验诊断学》
2023年第11期1269-1273,共5页
Chinese Journal of Laboratory Diagnosis
基金
河南省科技攻关计划(182102310140)
作者简介
通信作者:张喜红;田金,女,副主任医师,研究方向:子宫内膜异位症。
