摘要
目的:观察三阶梯止痛法治疗肝癌疼痛患者的效果。方法:回顾性分析2020年10月至2022年10月该院收治的102例肝癌疼痛患者的临床资料,根据治疗方法不同将其分为对照组和观察组各51例。对照组采用常规阿片类药物治疗,观察组采用三阶梯止痛法治疗。比较两组临床疗效,治疗前后视觉模拟评分法(VAS)评分、匹兹堡睡眠质量指数(PSQI)评分、疼痛相关指标[P物质(SP)、β-内啡肽(β-EP)、5-羟色胺(5-HT)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.16%(47/51),高于对照组的76.47%(39/51),差异有统计学意义(P<0.05);治疗后,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍等PSQI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血浆SP水平均低于治疗前,且观察组低于对照组,两组血浆β-EP和血清5-HT水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:三阶梯止痛法治疗肝癌疼痛患者可提高治疗总有效率,改善疼痛相关指标水平,降低VAS和PSQI评分,效果优于常规阿片类药物治疗。
Objective:To observe effects of three-step analgesic ladder therapy on patients with liver cancer pain.Methods:The clinical data of 102 patients with liver cancer pain admitted to this hospital from October 2020 to October 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,51 cases in each.The control group was treated with conventional opioids treatment,while the observation group was treated with three-step analgesic ladder therapy.The clinical efficacy,the visual analogue scale(VAS)score,the Pittsburgh sleep quality index(PSQI)score,the pain-related indicators[substance P(SP),β-endorphin(β-EP),5-hydroxytryptamine(5-HT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.16%(47/51),which was higher than 76.47%(39/51)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the VAS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PSQI scores of sleep quality,sleep time,sleep time,sleep efficiency,sleep disorder,hypnotic drugs and daytime dysfunction in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the plasma SP levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the levels of plasmaβ-EP and serum 5-HT in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Three-step analgesic ladder therapy can improve the total effective rate of treatment,improve the levels of pain-related indicators,and reduce the VAS scores and the PSQI scores in the patients with liver cancer pain.Moreover,it is superior to the conventional opioid treatment.
作者
杨文涛
YANG Wentao(Department of Pharmacy of Pingdingshan Hewu General Hospital,Pingdingshan 462500 Henan,China)
出处
《中国民康医学》
2023年第16期27-30,共4页
Medical Journal of Chinese People’s Health
关键词
三阶梯止痛法
肝癌
疼痛
睡眠质量
生命质量
不良反应
Three-step analgesic ladder therapy
Liver cancer
Pain
Sleep quality
Quality of life
Adverse reaction
作者简介
杨文涛(1985.03-),男,汉族,河南舞钢人,本科,主管药师,研究方向为药品调制、临床药学。
