摘要
目的 比较针刺结合耳穴贴敷与尼古丁透皮贴治疗中重度尼古丁依赖者的临床疗效和安全性。方法采用前瞻性随机对照试验,将符合中重度尼古丁依赖标准的64例自愿戒烟受试者通过随机数字表按1∶1分为治疗组和对照组,每组32例。治疗组采用针刺结合耳穴贴敷治疗,每周2次,4周为1个疗程,共进行2个疗程;对照组采用尼古丁透皮贴治疗,每天使用1个贴片,持续24 h,共治疗8周。疗程结束后观察两组治疗后、随访时(治疗后第16周)的治愈率;分别于治疗前后及随访时观察每日吸烟量、呼出一氧化碳(CO)值、尼古丁依赖量表(FTND)、明尼苏达尼古丁戒断症状量表(MNWS)、匹兹堡睡眠指数量表(PSQI)评分,并记录不良反应。结果 治疗组与对照组各30例完成治疗及随访。治疗组治疗后及随访时的治愈均为6例(治愈率均为20%);对照组分别为7例(23.3%)、5例(16.7%);两组治疗后及随访时的治愈率比较差异均无统计学意义(P>0.05)。两组治疗后和随访时的每日吸烟量、呼出CO值与治疗前比较均明显减少,差异具有统计学意义(P<0.05);而两组治疗后和随访时的组间比较差异均无统计学意义(P>0.05)。两组治疗后及随访时FTND、MNWS、PSQI评分较治疗前分值明显降低(P<0.05)。治疗后及随访时,两组FTND评分比较差异无统计学意义(P>0.05),而治疗组MNWS、PSQI评分均低于对照组(P<0.05)。结论针刺结合耳穴贴敷干预中重度尼古丁依赖者在提高中重度尼古丁依赖治愈率、降低尼古丁依赖程度上与一线药物尼古丁贴疗效相当,在缓解戒断症状及改善睡眠等方面优于尼古丁贴,且长期效果稳定。
Objective To compare the efficacy and safety of acupuncture combined with auricular acupoints patches and nicotine transdermal patch in treating moderate to severe nicotine dependence.Methods In a randomized controlled trial,64 quit smoking voluntary subjects with moderate to severe nicotine dependence were randomly divided at a ratio of 1∶1 into a treatment group and a control group,with 32 cases in each group.The treatment group was given acupuncture combined with auricular acupoints patches,twice weekly,four weeks as a course for two courses.The control group was given nicotine transdermal patch,one patch per day for 24 hours,8 weeks.The cure rate was assessed after treatment and at follow-up(the 16th week after treatment).The daily smoking volume,exhaled carbon monoxide(CO)value,Nicotine Dependence Scale(FTND),Minnesota Nicotine Withdrawal Symptoms Scale(MNWS),and Pittsburgh Sleepiness Index Inventory(PSQI)were evaluated before and after treatment and at followup,and adverse effects were recorded.Results In terms of the cure rate,there were both six cured cases(20%)after treatment and at follow-up in the treatment group,while in the control group,seven(23.3%)and five(16.7%)patients were cured after treatment and at follow-up,respectively,with no statistically significant differences between the two groups both after treatment and at follow-up(P>0.05).The daily smoking volume and exhaled CO value sig⁃nificantly decreased after treatment and at follow-up in both groups(P<0.05),but were not significantly different be⁃tween the groups after treatment and at follow-up(P>0.05).After treatment and at follow-up,FTND,MNWS,and PSQI scores were significantly reduced in both groups compared with those before treatment(P<0.05).There was no statistically significant difference in the FTND scale scores between the two groups after treatment and at follow-up(P>0.05),while the MNWS and PSQI scale scores were lower in the treatment group than in the control group(P<0.05).Conclusion Acupuncture combined with auricular acupoint patches for moderate to severe nicotine depen⁃dence has comparable effect with the first-line drug nicotine patch in terms of increasing the cure rate and decreasing the degree of nicotine dependence,and is superior to nicotine patch in terms of relieving withdrawal symptoms and im⁃proving sleep,with stable long-term effect.
作者
纪铠松
佘雅琳
陈悦轩
陆丽明
李虹竹
杨子宇
林国华
王澍欣
曾婧纯
JI Kaisong;SHE Yalin;CHEN Yuexuan;LU Liming;LI Hongzhu;YANG Ziyu;LIN Guohua;WANG Shuxin;ZENG Jingchun(The First Clinical College of Guangzhou University of Chinese Medicine,Guangzhou,510405;Affiliated TCM Hospital of Guangzhou Medical University;South China Research Center for Acupuncture and Moxibustion,Guangzhou University of Chinese Medicine;The First Affiliated Hospital of Guangzhou University of Chinese Medicine;Nanshan Hospital of Traditional Chinese Medicine,Shenzhen)
出处
《中医杂志》
CSCD
北大核心
2023年第17期1771-1776,共6页
Journal of Traditional Chinese Medicine
基金
广东省中医药局科研项目(20204005,20211128)
广州市科技计划项目(202102010505)
深圳市南山区卫生健康局引进高层次医学团队预立项项目(SZSM202103010)。
关键词
尼古丁依赖
针刺
耳穴贴敷
戒烟
随机对照试验
nicotine dependence
acupuncture
auricular acupressure
smoking cessation
randomized controlled study
作者简介
通讯作者:曾婧纯,tcm_zjc@126.com。
