摘要
糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是慢性高血糖引起微血管损伤的主要表现之一。迄今为止,关于DPN的发病机制尚不完全清楚。近几年,随着生物信息学和高通量测序技术的崛起,有研究报道miRNA-29可能参与了DPN的发病过程中的氧化应激、慢性炎症、胰岛素抵抗、血管内皮功能障碍等病理生理环节,但具体机制尚不明确。以下综述miRNA-29在DPN中的研究现状,以期为DPN的早期防治提供新的诊疗思路。
Diabetic peripheral neuropathy is one of the main manifestations of microvascular damage caused by chronic hyperglycemia.Up to now,the pathogenesis of diabetic peripheral neuropathy is not fully understood.In recent years,with the rise of bioinformatics and high-throughput sequencing technologies,some studies have reported that miRNA-29 is involved in the pathogenesis of diabetic peripheral neuropathy,for example,it may be involved in oxidative stress,chronic inflammation,insulin resistance,endothelial dysfunction and other pathological links,but it is still being explored.Therefore,this article reviews the research status about miRNA-29 in diabetic peripheral neuropathy,so as to provide new ideas for the early prevention and treatment of diabetic peripheral neuropathy.
作者
王扶卉
董俐
罗晓红
WANG Fuhui;DONG Li;LUO Xiaohong(Department of Endocrinology,The Second Hospital of Lanzhou University,Lanzhou,Gansu 730030,China;Department of Endocrinology,The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou,Gansu 730050,China)
出处
《安徽医药》
CAS
2023年第10期1915-1919,共5页
Anhui Medical and Pharmaceutical Journal
基金
中国人民解放军联勤保障部队第九四〇医院院内项目(2021xyky040)。
作者简介
通信作者:罗晓红,女,主任医师,硕士生导师,研究方向为糖尿病及其并发症,Email:lznfmluo@163.com。
