摘要
目的探讨低分子肝素联合硫酸镁治疗妊娠期高血压疾病(HDCP)的临床效果。方法抽取2020年3月至2022年3月周口市妇幼保健院收治的98例HDCP患者,以双色球法分为对照组和观察组,每组49例。对照组予以硫酸镁注射液治疗,观察组在对照组治疗基础上加用低分子肝素。比较两组患者的治疗效果,比较两组治疗前后的血压、心率、凝血指标,比较两组母婴不良妊娠结局。结果观察组治疗总有效率(95.92%,47/49)高于对照组(81.63%,40/49),母婴不良妊娠结局发生率(10.20%,5/49)低于对照组(26.53%,13/49),差异有统计学意义(P<0.05)。治疗前,两组血压、心率、凝血酶原时间、D-二聚体水平比较差异未见统计学意义(P>0.05);治疗后,观察组血压、心率、D-二聚体水平低于对照组,凝血酶原时间大于对照组,差异有统计学意义(P<0.05)。结论对于HDCP患者在硫酸镁治疗基础上加用低分子肝素,可提高疗效,更好地改善血压、心率及凝血指标,减少不良妊娠结局。
Objective To investigate the effect of low molecular weight heparin combined with magnesium sulfate injection in the treatment of hypertensive disorders of pregnancy(HDCP).Methods A total of 98 HDCP patients treated in the Zhoukou Maternal and Child Health Hospital from March 2020 to March 2022 were selected,and they were divided into control group and observation group by the dichromatic sphere method,with 49 cases in each group.The control group was given magnesium sulfate injection,and the observation group was given low molecular weight heparin based on the treatment of the control group.The curative effect of the two groups were compared.The preoperative and postoperative blood pressure,heart rate and coagulation indexes were compared between the two groups.And the maternal and neonatal adverse outcomes of the two groups were compared.Results The total effective rate of the observation group(95.92%,47/49)was higher than that of the control group(81.63%,40/49),and rate of maternal and neonatal adverse outcome of the observation group(10.20%,5/49)was lower than that of the control group(26.53%,13/49),and the difference was statistically significant(P<0.05).There was no significant difference in blood pressure,heart rate,prothrombin time,D-dimer level between the two groups before treatment(P>0.05).After treatment,blood pressure,heart rate,D-dimer level in the observation group were lower,while prothrombin time in the observation group was higher,compared with the control group(P<0.05).Conclusions Using low molecular weight heparin combined with magnesium sulfate injection,in the treatment of HDCP patients,can improve the curative effect,better improve blood pressure,heart rate and coagulation indexes,which is beneficial to decrease adverse pregnancy outcomes.
作者
董丽涛
Dong Litao(Department of Obstetrics,Zhoukou Maternal and Child Health Hospital,Zhoukou 466000,China)
出处
《中国实用医刊》
2023年第6期97-100,共4页
Chinese Journal of Practical Medicine
关键词
低分子肝素
妊娠期高血压疾病
血压
不良妊娠结局
Heparin,low-molecular-weight
Hypertensive disorders of pregnancy
Blood pressure
Adverse pregnancy outcomes
作者简介
董丽涛,Email:dlt197000@163.com。
