摘要
目的观察吸入用乙酰半胱氨酸溶液联合雾化吸入重组人干扰素α2b(rhIFNα2b)治疗小儿病毒性肺炎的临床疗效。方法选取安徽省妇幼保健院2019年9月至2021年3月收治住院的病毒性肺炎病儿100例,依据随机数字表法,把病例分为对照组和观察组,每组50例。对照组病儿给予常规治疗同时雾化吸入rhIFNα2b注射液,每次200000 IU/kg,每天2次;观察组在对照组基础上予吸入用乙酰半胱氨酸溶液每次3 mL雾化吸入治疗,每天2次。通过观察两组病例病毒性肺炎的转归,比较两组病例咳嗽缓解天数、肺部啰音消失的天数、住院天数,及两组治疗的总有效率和不良反应发生率。结果观察组病例咳嗽缓解天数、肺部啰音消失天数、住院天数均低于对照组(P<0.05);观察组病例治疗总有效率94.0%(47/50),对照组病例治疗总有效率80.0%(40/50),两组差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论吸入用乙酰半胱氨酸溶液联合rhIFNα2b雾化吸入治疗小儿病毒性肺炎疗效显著,不良反应发生率无显著增加,值得临床推广应用。
Objective To observe the clinical efficacy of inhalation of acetylcysteine solution combined with atomized inhalation of recombinant human interferonα2b(rhIFNα2b)in the treatment of pediatric viral pneumonia.Methods A total of 100 children with viral pneumonia admitted to Anhui Maternal and Child Health Hospital from September 2019 to March 2021 were selected,and the cases were divided into a control group and an observation group based on the method of randomized numerical table,with 50 cases in each group.Children in the control group were given routine treatment and nebulized inhalation of rhIFNα2b injection at 200000 IU/kg twice a day,while children in the observation group were given inhalation of acetylcysteine solution at 3 mL twice a day on the basis of the control group.By observing the regression of viral pneumonia in the two groups,we compared the number of days of cough relief,the number of days of disappearance of lung rales,the number of days of hospitalization,the total effective rate and the incidence rate of adverse reactions in the two groups.Results The cough relief days,lung rales disappearance days and hospital days in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the treatment of cases in the observation group was 94.0%(47/50),and the total effective rate of the treatment of cases in the control group was 80.0%(40/50);the difference was statistically significant(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion The efficacy of inhaled acetylcysteine solution combined with rhIFNα2b atomization inhalation for the treatment of pediatric viral pneumonia is significant,with no significant increase in the incidence of adverse reactions,and is worthy of clinical promotion and application.
作者
李冰
王慧琴
万燕明
李小燕
LI Bing;WANG Huiqin;WAN Yanming;LI Xiaoyan(Department of Pediatrics,Maternal and Child Health Hospital of Anhui Province,Hefei,Anhui 230001,China;Department of Neonatology,Maternal and Child Health Hospital of Anhui Province,Hefei,Anhui 230001,China)
出处
《安徽医药》
CAS
2023年第9期1874-1876,共3页
Anhui Medical and Pharmaceutical Journal
基金
合肥市卫生健康委2021年度应用医学研究项目(Hwk2021zd016)。
作者简介
通信作者:李小燕,女,副主任医师,研究方向为儿童呼吸系统疾病学,Email:1801736240@qq.com。
