摘要
目的探究蛋白信号调节因子4(RGS4)、趋化因子受体趋化因子受体4(CX-CR4)、拓扑异构酶Ⅱα(TOPOⅡα)在小儿肾母细胞瘤组织中的表达及其与临床病理特征和预后的关系。方法选取2017年1月至2020年1月于海南医学院第二附属医院行手术治疗的肾母细胞瘤40例患儿为研究对象,并留距离癌组织边缘>4 cm的癌旁组织40例作为对照。探究RGS4蛋白、CXCR4、TOPOⅡα表达水平与肾母细胞瘤患儿临床病理特征及生存时间之间的关系。结果与癌旁组织对比,肾母细胞瘤组织中TOPOⅡα、CXCR4的高表达率升高,RGS4蛋白高表达率下降(P<0.05)。RGS4蛋白与淋巴结转移、病理种类、复发转移、TNM分期呈负相关;CXCR4、TOPOⅡα与其呈正相关(P<0.05)。RGS4蛋白、CXCR4、TOPOⅡα与复发转移、病理种类、淋巴结转移、TNM分期有关(P<0.05)。RGS4蛋白高表达者总生存率较高,CXCR4、TOPOⅡα高表达的患儿总生存率较低。结论小儿肾母细胞瘤组织中RGS4蛋白、CXCR4及TOPOⅡα的表达变化与临床病理特征变化和预后生存密切相关。
Objective To explore the expressions of protein signaling regulator 4(RGS 4),chemokine receptor chemokine receptor 4(CXCR4),topoisomeraseα(TOPOⅡα)in pediatric Wilms tumor tissues and their relationships with clinicopathological characteristics and prognosis.Methods The cancer tissues of 40 children with nephroblastoma treated by surgery in The second Affiliated Hospital of Hainan Medical University from January 2017 to January 2020 were selected as the study subjects,40 with adjacent tissues>4 cm away from the edge of cancer tissue kept as controls.The relationship between the expressions of RGS 4 protein,CXCR 4 and TOPOⅡα and the clinicopathological characteristics and survival time in children with Wilms'tumor.Results Compared with the paracancer tissues,the high expression rates of TOPOⅡα and CXCR4 in Wilms tumor tissues were significantly increased,while the high expression rates of RGS4 protein were significantly decreased(P<0.05).RGS4 protein was negatively correlated with lymph node metastasis,pathological type,recurrence and metastasis,and TNM stage.CXCR4 and TOPOⅡα were positively correlated with them(P<0.05).RGS4,CXCR4 and TOPOⅡαwere correlated with recurrence and metastasis,pathological type,lymph node metastasis and TNM stage(P<0.05).Those with high expression of RGS4 protein had higher overall survival rate,while those with high expressions of CXCR4 and TOPOⅡα had lower overall survival rate.Conclusion The expressions of RGS4 protein,CXCR4 and TOPOⅡα in pediatric tissues are closely associated with the clinicopathological characteristics and prognosis survival.
作者
徐莉
陈运旺
廖赵妹
林强
陈乙云
XU Li;CHEN Yunwang;LIAO Zhaomei;LIN Qiang;CHEN Yiyun(Department of Pediatrics,the Second Affiliated Hospital,Hainan Medical College,Haikou 570311,China)
出处
《实用医学杂志》
CAS
北大核心
2023年第14期1793-1797,共5页
The Journal of Practical Medicine
基金
海南省卫生健康行业科研项目(编号:22A200267)。
