摘要
铁死亡是一种铁依赖性程序性细胞死亡方式,具体调控机制仍未明了。研究发现肺癌与铁死亡密切相关,铁死亡诱导剂促进肺癌细胞死亡。该文阐述了铁死亡调控机制及其在肺癌中作用,分析了铁死亡在肺癌治疗中潜在价值。
Ferroptosis is an iron-dependent mode of programmed cell death,but its definite regulatory mechanism remains unclear.Recent studies have found that lung cancer is closely related to ferroptosis,and ferroptosis inducers promote the death of lung cancer cell.This article reviews the regulatory mechanism of ferroptosis and its role in lung cancer,and analyzes the potential value of ferroptosis in lung cancer therapy.
作者
黄裕锋
向静
陈春源
邓彪
王薛枫
罗连响
梁柱
HUANG Yu-feng;XIANG Jing;CHEN Chun-yuan;DENG Biao;WANG Xue-feng;LUO Lian-xiang;LIANG Zhu(Guangdong Medical University,Zhanjiang 524023,China;Department of Thoracic Surgery,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China;Department of Cardiothoracic Surgery,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
出处
《广东医科大学学报》
2023年第4期444-455,共12页
Journal of Guangdong Medical University
基金
国家自然科学基金面上项目(81572786)
广东省中医药局科研项目(20222107)。
关键词
铁死亡
肺癌
免疫治疗
ferroptosis
lung cancer
immunotherapy
作者简介
黄裕锋(1994-),男,医学硕士,医师,E-mail:hyfxj@gdmu.edu.cn;通信作者:梁柱(1979-),男,硕士,副主任医师,E-mail:liangzhu186@163.com。
