摘要
近年来铁死亡与急性肾损伤(AKI)关系的研究不断深入,但是铁死亡在核辐射导致的AKI中发挥作用的分子生物学机制尚未阐明。本文综述了铁死亡在核辐射所致AKI生物学过程中的作用研究进展,以便为防治核辐射所致AKI寻找潜在的检测手段和治疗靶点。
In recent years,the research on the relationship between ferroptosis and acute kidney injury(AKI)has been deepening,but the molecular biological mechanism of ferroptosis in AKI caused by nuclear radiation has not been clarified.This article reviewed the progress of research on the role of ferroptosis in the biological process of AKI induced by nuclear radiation so as to look for the potential detection methods and therapeutic targets for treating AKI induced by nuclear radiation.
作者
李燕辰
李建宁
涂晓文
李峰生
Yanchen Li;Jianning Li;Xiaowen Tu;Fengsheng Li(Postgraduate Training Base of Jinzhou Medical University in PLA Rocket Force Characteristic Medical Center,Beijing 100086;Department of Nephrology,PLA Rocket Force Characteristic Medical Center,Beijing 100086;Department of Biochemistry Teaching Research,Ningxia Medical University,Yinchuan 750021,Ningxia Hui Autonomous Region;Laboratory of Scientific Research Department,PLA Rocket Force Characteristic Medical Center,Beijing 100086,China)
出处
《中华肾病研究电子杂志》
2022年第6期338-341,共4页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
关键词
铁死亡
急性肾损伤
核辐射
谷胱甘肽过氧化物酶
活性氧
脂质过氧化物
Ferroptosis
Acute kidney injury
Nuclear radiation
Glutathione peroxidase
Reactive oxygen species
Lipid peroxides
作者简介
通信作者:涂晓文,Email:xiaowentu@126.com;通信作者:李峰生,Email:lifs0624@163.com
