摘要
心力衰竭(heart failure,HF)是心脏结构或功能受损而导致的一种严重进展性临床综合征,为多种心脏疾病发展的终末期阶段。欧洲心脏病学会在2021年HF诊断和治疗的指南中提出HF分为三类:射血分数保留型心力衰竭(heart failure with pre⁃served ejection fraction,HFpEF)、射血分数降低型心力衰竭(heart failure with reduced ejection fraction,HFrEF)和射血分数轻度降低型心力衰竭(heart failure with mildly reduced ejection fraction,HFmrEF)。
Heart failure(HF)with preserved ejection fraction(HFpEF)accounts for half of all patients with HF,confers substantial morbidity and mortality,but has no effective therapy to improve outcomes.This is mainly due to incomplete understanding of its pathological mechanisms.The pathophysiological mechanisms of HFpEF are of great heterogeneity and diversity,in which cardiac structure and function dysfunction,systemic inflammation,and energy metabolism are all involved.The lack of appropriate standard HFpEF animal models also hampered the mechanism exploration and drug development.This review summarizes the current knowledge regarding the pathophysiology and the preclinical animal models for HFpEF.
作者
祝欣欣
张琦
陈芸儿
于宝琪
王霞
曲爱娟
ZHU Xinxin;ZHANG Qi;CHEN Yuner;YU Baoqi;WANG Xia;QU Aijuan(Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Key Labo-ratory of Remodeling-Related Cardiovascular Diseases,Ministry of Education,Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases,Beijing 100069,China;Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing Key Laboratory for HIV/AIDS Research,Beijing 100069,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2023年第8期1499-1508,共10页
Chinese Journal of Pathophysiology
基金
北京市自然科学基金资助项目(No.KZ202010025032)
北京市教委长城学者计划(No.CIT&TCD20190332)。
关键词
射血分数保留型心力衰竭
炎症
代谢综合征
heart failure with preserved ejection fraction
inflammation
metabolic syndrome
作者简介
通讯作者:曲爱娟,Tel:010-83950496,E-mail:aijuanqu@ccmu.edu.cn。
