摘要
干细胞具有自我更新和多向分化的能力,在组织工程和再生医学领域被认为有广泛的应用前景。然而,干细胞的功能依赖于自身所处的微环境即干细胞龛。干细胞龛中包含复杂的生物物理和生物化学因素。最近的研究表明,生物物理因素即干细胞所处的物理微环境在调控干细胞定向分化中发挥着重要的作用。在体外,人工合成的物理微环境能够精确操控多种生物物理特性。在此基础上,研究者进一步开展了如基质硬度、基质形貌和机械力等生物物理特性对各种不同种类的干细胞定向分化功能影响的研究。本文总结了人工构建物理微环境的手段及力学模型,并且综述了不同生物物理特性对干细胞分化影响的研究现状,希望对今后相关领域的研究发展提供参考借鉴。
Stem cells have been regarded with promising application potential in tissue engineering and regenerative medicine due to their self-renewal and multidirectional differentiation abilities.However,their fate is relied on their local microenvironment,or niche.Recent studied have demonstrated that biophysical factors,defined as physical microenvironment in which stem cells located play a vital role in regulating stem cell committed differentiation.In vitro,synthetic physical microenvironments can be used to precisely control a variety of biophysical properties.On this basis,the effect of biophysical properties such as matrix stiffness,matrix topography and mechanical force on the committed differentiation of stem cells was further investigated.This paper summarizes the approach of mechanical models of artificial physical microenvironment and reviews the effects of different biophysical characteristics on stem cell differentiation,in order to provide reference for future research and development in related fields.
作者
李驰宇
樊瑜波
郑丽沙
LI Chiyu;FAN Yubo;ZHENG Lisha(Key Laboratory of Biomechanics and Mechanobiology,Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
北大核心
2023年第4期609-616,共8页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(32171310,11972067,U20A20390,11827803)
中央高校基本科研业务费,“111”计划(B13003)。
关键词
干细胞
分化
微环境
生物物理信号
Stem cells
Differentiation
Microenvironment
Biophysical cues
作者简介
通信作者:郑丽沙,Email:lishazheng@buaa.edu.cn。
