摘要
眼接受外界光刺激产生的视觉信号经视觉通路到达视觉中枢,经中枢加工整合形成的主观感觉称为脑视觉。脑视觉反映了从视网膜到视觉中枢整个视觉神经系统的功能。既往在电生理、磁共振成像(MRI)、功能性近红外光谱技术(fNIRS)等检测中均发现近视患者的脑视觉异常。电生理检查的异常人群主要为高度近视和病理性近视患者。MRI检查发现高度近视患者多个视觉相关脑区的结构和功能发生了异常改变。本团队近期应用近红外脑功能成像技术结合自主研发的设备对不同类型近视患者的脑功能进行了研究,研究结果提示病理性近视患者的脑视觉和成年中度近视患者在无屈光矫正状态下的脑视觉均存在异常。近视儿童眼调节过程的脑视觉机制有待深入研究。本文从近视的分类,近视的脑视觉研究方法以及近视的视觉电生理学、MRI、fNIRS研究等方面就近视的脑视觉研究现状及展望进行综述。
The visual signal generated by the eye receiving external light stimulation reaches the visual center through the visual pathway and is processed and integrated by the visual center to form a subjective sensation called cerebral vision.Cerebral vision reflects the function of the whole visual nervous system from the retina to the visual cortex.Abnormal cerebral vision has been found in myopes using electrophysiology,magnetic resonance imaging(MRI)and functional near-infrared spectroscopy(fNIRS).The abnormal electrophysiological results are mainly found in patients with high myopia and pathological myopia.MRI shows abnormal changes in the structure and function of several vision-related brain regions in patients with high myopia.Recently,by applying near-infrared brain function imaging technology combined with self-developed equipment,our team conducted a series of studies on the brain function of myopic patients and found that adult patients with moderate myopia and patients with pathological myopia have the abnormal cerebral vision.The mechanism of neural regulation of eye accommodation in myopic children needs further investigation.In this article,we reviewed the current status and outlook of myopic brain vision research in terms of myopia classification,myopic brain vision research methods,and myopic visual electrophysiology,MRI,and fNIRS studies.
作者
龚胜(综述)
毕爱玲
毕宏生(审校)
Gong Sheng;Bi Ailing;Bi Hongsheng(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Shandong Academy of Eye Disease Prevention and Therapy,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Jinan 250002,China;Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Shandong Academy of Eye Disease Prevention and Therapy,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Jinan 250002,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2023年第8期812-817,共6页
Chinese Journal Of Experimental Ophthalmology
基金
国家重点研发计划项目(2019YFC1710204)
国家自然科学基金面上项目(82074498)。
关键词
近视
视网膜电图
视觉诱发电位
近红外光谱技术
磁共振成像
脑视觉
Myopia
Electroretinography
Evoked potentials,Visual
Spectroscopy,near-Infrared
Magnetic resonance imaging
Cerebral vision
作者简介
通信作者:毕宏生,Email:hongshengbi1@163.com。
