摘要
蛛网膜下腔出血后早期脑损伤是指发生在血管痉挛前,蛛网膜下腔出血后72h内大脑发生的一系列变化,包括脑灌注变化、炎症反应、活性氧自由基的产生、皮质弥散去极化、血脑屏障破坏及神经细胞死亡等。本文主要总结了目前早期脑损伤发生的研究最新进展,旨在为蛛网膜下腔出血后早期脑损伤研究及治疗提供依据。
Early brain injury(EBI)after Subarachnoid hemorrhage(SAH)refers to a series of changes in the brain within 72 hours after subarachnoid hemorrhage,which occurred before vasospasm,including cerebral perfusion,inflammatory response,generation of reactive oxygen species,cortical diffusion depolarization,destruction of blood-brain barrier and death of nerve cells.This article reviews the current progress of EBI to provide a theoretical foundation for the study of EBI after SAH.
作者
王东森(综述)
吴庆建(审校)
WANG Dongsen;WU Qingjian(School of Clinical Medicine,Jining Medical University,Jining 272013,China;Department of Emergency,Jining NO.1 People's Hospital,Jining 272011,China)
出处
《济宁医学院学报》
2023年第4期278-282,共5页
Journal of Jining Medical University
基金
山东省自然科学基金面上项目(ZR2021MH133)。
关键词
蛛网膜下腔出血
早期脑损伤
病理生理机制
Subarachnoid hemorrhage
Early brain injury
Pathophysiologic mechanism
作者简介
通信作者:吴庆建,E-mail:wqw110@163.com。
