摘要
目的:探究亚胺培南联合多巴胺治疗重症肺炎的效果及对炎症反应的影响。方法:选取如皋市中医院2017年1月—2022年3月收治的115例重症肺炎患者作为本次研究对象,采用随机数字表法将其分为对照组和研究组。对照组(n=58)在常规治疗基础上增加亚胺培南治疗,研究组(n=57)在常规治疗基础上增加亚胺培南与多巴胺治疗。比较两组临床疗效、炎症反应、免疫功能及不良反应发生情况。结果:研究组治疗总有效率明显高于对照组(P<0.05)。治疗前,两组降钙素原(PCT)、白细胞介素-10(IL-10)、C反应蛋白(CRP)、白细胞计数(WBC)水平比较,差异均无统计学意义(P>0.05);治疗后,两组PCT、IL-10、CRP、WBC水平均较治疗前有明显下降,研究组均明显低于对照组(P<0.05)。治疗前,两组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异均无统计学意义(P>0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前有明显升高,研究组均明显高于对照组(P<0.05);治疗后,两组CD8^(+)较治疗前明显下降,研究组明显低于对照组(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:对重症肺炎患者予以亚胺培南联合多巴胺治疗,临床疗效有明显提升,炎症因子水平及免疫功能有明显改善,且不会增加不良反应,临床安全性较高。
Objective:To investigate the effect of Imipenem combined with Dopamine on severe pneumonia and its effect on inflammatory reaction.Method:A total of 115 patients with severe pneumonia admitted to Rugao City Hospital of Traditional Chinese Medicine from January 2017 to March 2022 were selected as the subjects of this study,and were divided into control group and study group according to random number table method.The control group(n=58)was treated with Imipenem on the basis of conventional treatment,and the study group(n=57)was treated with Imipenem combined with Dopamine on the basis of conventional treatment.The clinical efficacy,inflammatory reaction,immune function and occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of the study group was higher than that of the control group(P<0.05).Before treatment,there were no significant differences in the levels of procalcitonin(PCT),interleukin-10(IL-10),C reactive protein(CRP)and white blood cell count(WBC)between the two groups(P>0.05).After treatment,the levels of PCT,IL-10,CRP and WBC in both groups were significantly lower than before treatment,and those in the study group were significantly lower than those in the control group(P<0.05).Before treatment,there were no significant differences in the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups(P>0.05).After treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in both groups were significantly higher than before treatment,and those in the study group were significantly higher than those in the control group(P<0.05).After treatment,CD8^(+)decreased significantly in both groups,and that in the study group was significantly lower than that in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Imipenem combined with Dopamine in the treatment of severe pneumonia has significantly improved clinical efficacy,inflammatory factor levels and immune function,and does not increase adverse reactions,and has high clinical safety.
作者
周铁君
马菲菲
陆宝荣
彭智丽
ZHOU Tiejun;MA Feifei;LU Baorong;PENG Zhili(Rugao City Hospital of Traditional Chinese Medicine,Jiangsu Province,Rugao 226500,China;不详)
出处
《中国医学创新》
CAS
2023年第22期57-61,共5页
Medical Innovation of China
关键词
重症肺炎
亚胺培南
多巴胺
炎症反应
免疫功能
Severe pneumonia
Imipenem
Dopamine
Inflammatory reaction
Immune function
作者简介
通信作者:周铁君。
