摘要
目的:探讨凝血酶散、血凝酶、奥美拉唑联合治疗消化性溃疡合并上消化道出血的效果。方法:选取2019年8月—2022年8月吉安市第一人民医院收治的消化性溃疡合并上消化道出血患者82例,通过随机数字表法分为对照组与观察组,各41例。对照组奥美拉唑治疗,观察组给予凝血酶散、血凝酶及奥美拉唑联合治疗。比较两组输血量、相关症状改善情况、治疗效果、凝血功能指标[纤维蛋白原(FIB)、血小板计数(PLT)、活化部分凝血活酶时间(APTT)]、细胞因子[血管内皮生长因子(VEGF)、超氧化物歧化酶(SOD)、表皮生长因子(EGF)]及不良反应发生情况。结果:观察组治疗总有效率为95.12%,高于对照组的78.05%(P<0.05)。用药后,观察组输血量少于对照组,溃疡愈合时间、出血停止时间均早于对照组(P<0.05)。用药后,两组FIB、PLT水平均上升,观察组均高于对照组(P<0.05);用药后,两组APTT水平均下降,观察组低于对照组(P<0.05)。用药后两组VEGF、SOD、EGF均上升,且观察组均高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)结论:凝血酶散、血凝酶、奥美拉唑联合方案用于消化性溃疡合并上消化道出血患者中效果理想,安全性可靠,不仅能够有效减少出血量,缓解临床症状,还能增强凝血功能,促进溃疡创面愈合,加快身体恢复。
Objective:To explore the effect of Thrombin Powder,Hemagglutinin and Omeprazole in the treatment of peptic ulcer with upper gastrointestinal bleeding.Method:A total of 82 patients with peptic ulcer complicated with upper gastrointestinal bleeding who were treated in the First People's Hospital of Ji’an City from August 2019 to August 2022 were selected,and were divided into control group and observation group by random number table method,with 41 cases in each group.The control group was treated with Omeprazole,and the observation group was treated with Thrombin Powder,Hemocoagulase and Omeprazole.Blood transfusion volume,improvement of related symptoms,therapeutic effect,coagulation function index[fibrinogen(FIB),platelet count(PLT),activated partial thromboplastin time(APTT)],cytokines[vascular endothelial growth factor(VEGF),superoxide dismutase(SOD),epidermal growth factor(EGF)]and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 95.12%,which was higher than 78.05%of the control group(P<0.05).After treatment,the blood transfusion volume in the observation group was less than that in the control group,and the ulcer healing time and bleeding stopping time were earlier than those in the control group(P<0.05).After treatment,the levels of FIB and PLT were increased in both groups,and those in the observation group were higher than those in the control group(P<0.05).After treatment,APTT levels in both groups decreased,and the observation group was lower than the control group(P<0.05).After treatment,VEGF,SOD and EGF were increased in both groups,and the observation group were higher than those of the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Thrombin Powder,Hemocoagulase and Omeprazole in the patients with peptic ulcer and upper gastrointestinal bleeding has ideal effect and is safe and reliable.It can not only effectively reduce blood loss and relieve clinical symptoms,but also enhance coagulation function,promote ulcer wound healing and accelerate body recovery.
作者
彭解华
PENG Jiehua(The First People's Hospital of Ji’an City,Jiangxi Province,Ji’an 343000,China)
出处
《中国医学创新》
CAS
2023年第22期40-45,共6页
Medical Innovation of China
关键词
消化性溃疡
上消化道出血
凝血酶散
血凝酶
奥美拉唑
凝血功能
血管状态
Peptic ulcer
Upper gastrointestinal bleeding
Thrombin Powder
Hemocoagulase
Omeprazole
Coagulation function
Vascular status
作者简介
通信作者:彭解华。
