摘要
With the rise of optogenetic manipulation of neurons,the effects of optogenetic heating on temperature-sensitive physi-ological processes,and the damage to surrounding tissues have been neglected.This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber(TSOHF)using the integrated dynamic wet-spinning technique.TSOHF exhibits a structural tunable diameter,clear core/sheath structure,tunable temperature-sensitivity,excellent light propagation property(0.35 dB cm^(-1),650 nm laser light),and good biocompatibility(including tissue-like Young’s modulus,stable dimensional stability,and low cytotoxicity).Based on these properties,a potential application of optogenetic regulation of neural tissue(hypoglossal nerve),with controllable temperature using TSOHF was designed and performed.Further,this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine.
基金
supported by the Shanghai Stomatological Hospital Science and Technology Talents Project(SSH-2022-KJCX-B01)
National Key Research and Development Program of China(2021YFA1201302/2021YFA1201300)
the National Natural Science Foundation of China(NO.52173029
NO.51733002
NO.51803022)
Guoyin Chen thanks for the support from the fellowship of China National Postdoctoral Program for Innovative Talents under Grant BX20220063,and Graduate Student Innovation Fund of Donghua University(CUSF-DH-D-2020038).
作者简介
Guoyin Chen,contributed equally;Siming Xu,contributed equally;Yuehua Liu,liuyuehua@fudan.edu.cn;Kai Hou,houkai711@dhu.edu.cn;Jie Pan,jiepan@fudan.edu.cn。
