摘要
目的:探究丁苯酞对急性脑梗死患者的疗效及对睡眠质量的影响作用。方法:选取2020年2月至2021年8月收治的急性脑梗死患者120例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组60例。观察组患者给予丁苯酞治疗,对照组患者未给予丁苯酞治疗,其余治疗方法相同。比较分析2组患者治疗效果、神经功能及睡眠质量等的改善情况。结果:观察组治疗有效率为96.67%,明显高于对照组的83.33%,差异有统计学差意义(P<0.05)。2组患者治疗后睡眠质量均得到显著性改善,但观察组治疗后的睡眠质量评分为(5.17±1.29)分,显著低于对照组的(8.83±2.06)分,差异有统计学意义(P<0.05)。2组患者治疗后神经功能均得到显著性改善,但观察组治疗后的神经功能评分为(5.17±1.16)分,明显低于对照组的(8.38±2.04)分(P<0.05)。治疗后,观察组患者的炎性水平指标IL-6、CRP、TNF-α分别是(4.41±1.12)pg/mL、(5.08±1.16)ng/mL和(6.15±2.44)ng/mL,均明显小于对照组的(6.12±1.01)pg/mL、(7.94±1.43)ng/mL和(8.86±2.78)ng/mL(P<0.05)。结论:在急性脑梗死患者治疗中,丁苯酞可以有效改善其神经功能、睡眠质量,并且降低炎性水平,对其的恢复治疗具有重要作用。
Objective:To explore the curative effect of butylphthalide on patients with acute cerebral infarction and its effect on sleep.Methods:A total of 120 patients with acute cerebral infarction admitted to Liaocheng People′s Hospital from February 2020 to August 2021 were selected as the study subjects.Based on the random number table method,they were divided into the observation group(n=60 cases,treated with butylphthalide)and the control group(n=60 cases,treated without butylphthalide),other treatment method is same.The treatment effect,neurological function and sleep quality of the two groups were compared and analyzed.Results:The effective rate of treatment in the observation group was 96.67%,which was significantly higher than 83.33%in the control group and the difference was statistically significant(P<0.05).The sleep quality of patients in both groups was significantly improved after treatment,but the sleep quality score of the observation group after treatment(5.17±1.29)was significantly lower than that of the control group(8.83±2.06)and the difference was statistically significant(P<0.05).The neurological function of patients in both groups was significantly improved after treatment,but the neurological function score of the observation group after treatment(5.17±1.16)was significantly lower than that of the control group(8.38±2.04)(P<0.05).After treatment,the inflammatory level indexes of patients in the observation group were IL-6,CRP,TNF-αwere(4.41±1.12)pg/mL,(5.08±1.16)ng/mL and(6.15±2.44)ng/mL and were significantly lower than the control group which were(6.12±1.01)pg/mL,(7.94±1.43)ng/mL and(8.86±2.78)ng/mL in the control group(P<0.05).Conclusion:In the treatment of patients with acute cerebral infarction,butylphthalide can effectively improve neurological function,sleep quality,and effectively reduce the inflammatory level,which has an important role in the recovery of patients.
作者
芦倩
史磊
LU Qian;SHI Lei(Department of Neurology,Liaocheng People′s Hospital,Liaocheng 252000,China)
出处
《世界睡眠医学杂志》
2023年第4期709-711,715,共4页
World Journal of Sleep Medicine
关键词
脑梗死
丁苯酞
疗效
睡眠质量
作用
Cerebral infarction
Butyl phthalide
Efficacy
Sleep quality
Effect
作者简介
通信作者:史磊,E-mail:15063518668@163.com。
