摘要
松油烯-4-醇在自然界中含量非常丰富,作为一种环状单萜类化合物在多种天然植物中均有分布,为白千层精油、珊瑚姜精油等多种中药精油中的主要成分和关键活性物质。松油烯-4-醇具有抗微生物、抗肿瘤、杀虫、抗炎等作用,能够治疗肿瘤、口腔和心血管系统等方面的疾病,并且安全性好。在抗细菌方面,松油烯-4-醇能够破坏细菌细胞壁,提高细胞膜通透性,调控细菌迁徙繁衍等相关基因来抑制细菌活性;在抗真菌方面,松油烯-4-醇能够与真菌细胞壁中的麦角固醇结合引起真菌死亡;在杀虫方面,松油烯-4-醇能够抑制试验虫体内的Na^(+)、K^(+)-ATP酶活性引起试验虫死亡;在抗癌方面,松油烯-4-醇能够调节癌细胞中与凋亡有关蛋白表达,从而控制癌细胞凋亡。该文对其药理活性和作用机制研究状况作概述,以期望为松油烯-4-醇进一步研究与开发利用提供参考。
Terpine-4-ol is abundant in nature.As a cyclic monoterpenoid compound,terpine-4-ol is distributed in a variety of natural plants.It is the main component and the key active substance in many traditional Chinese essential oils,such as Melaleuca alba essential oil and coral ginger essential oil.Terpine-4-ol has anti-microbial,anti-tumor,insecticidal,anti-inflammatory,and other effects.It can treat cancer,as well as oral and cardiovascular diseases with great safety.In terms of antibacterial activity,terpine-4-ol can destroy bacterial cell walls,improve membrane permeability,and regulate bacterial migration,reproduction,and other related genes to inhibit bacterial activity.In terms of antifungal activity,terpine-4-ol can bind with ergosterol in fungal cell walls to cause fungal death.In terms of insecticidal activity,terpine-4-ol can inhibit Na^(+) and K^(+)-ATPase activity and cause the death of the insect.In terms of anticancer activity,terpine-4-ol can regulate the expression of apoptosis-related proteins in cancer cells,so as to control the apoptosis of cancer cells.In this paper,the pharmacological activity and action mechanism of terpine-4-ol were reviewed to provide a reference for further research and utilization of terpine-4-ol.
作者
杜清
钟雨樨
杨明
陈蕾
曾慧敏
艾崇文
管咏梅
DU Qing;ZHONG Yuxi;YANG Ming;CHEN Lei;ZENG Huimin;AI Chongwen;GUAN Yongmei(Key Laboratory of Modern Chinese Medicine Preparation,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第14期265-271,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
2020年度江西省教育厅科学技术研究项目(GJJ201251)
江西省高层次高技能领军人才培养工程项目(12623001)。
关键词
松油烯-4-醇
萜品烯4醇
单萜
药理活性
作用机制
terpinen-4-ol
terpene 4 alcohol
monoterpene
pharmacological activity
action mechanism
作者简介
第一作者:杜清,在读博士,讲师,从事中药新制剂与新技术研究,E-mail:1160144948@qq.com;通信作者:管咏梅,博士,教授,硕士生导师,从事中药新制剂与新技术及食疗学研究,E-mail:guanym2008@163.com。
