摘要
抑郁症是最常见的精神类疾病之一,有着高患病率、高致残率以及高复发率的特点,其病因及发病机制十分复杂,至今仍未完全阐明。神经递质在维持脑内化学平衡方面起着关键作用,近年来已有多数研究表明,神经递质与抑郁症的发病和治疗有着密切联系。因此,研究与抑郁症相关的神经递质有可能为抑郁症的发病机制及治疗策略提供研究靶点与思路。该文综述了近期国内外有关神经递质功能与抑郁症发病的研究成果,旨在解析当前研究较多的神经递质功能与抑郁症发病的深入联系,为后续探索抑郁症发病机制与诊疗策略提供研究思路。
Depression is one of the most common psychiatric disorders with high prevalence,disability and relapse rates,and its etiology and pathogenesis are complex and still not fully understood.Neurotransmitters play a key role in maintaining chemical homeostasis in brain,and many studies have shown a strong link between neurotransmitters and the development and treatment of depression in recent years.Therefore,studying the neurotransmitters associated with depression has the potential to provide research targets and ideas for the pathogenesis and treatment strategies of depression.This paper reviews the recent domestic and foreign research results on neurotransmitter function and the pathogenesis of depression,aiming to analyze the in-depth relationship between neurotransmitter function and the pathogenesis of depression,and provide research ideas for the follow-up exploration of the pathogenesis and diagnosis and treatment strategies of depression.
作者
姚娇
杨岩涛
艾启迪
林美妤
孙洋
龙俊鹏
阳松威
陈乃宏
YAO Jiao;YANG Yan-tao;AI Qi-di;LIN Mei-yu;SUN Yang;LONG Jun-peng;YANG Song-wei;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第7期1217-1221,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No.82130109,81730096)
湖南中医药大学中药学一流学科项目(校行科字【2018】3号)
湖南省中药饮片标准化及功能工程技术研究中心项目及开放基金项目(No.2016TP2008)
湖南中医药大学科研项目(No.2021XJJJ028)
湖南中医药大学科研启动计划项目。
作者简介
姚娇(2000-),女,硕士生,研究方向:中药药理学,E-mail:1416863261@qq.com;通信作者:阳松威(1990-),男,博士,讲师,研究方向:中药神经精神药理学,E-mail:646972015@qq.com;通信作者:陈乃宏(1961-),男,博士,研究员,研究方向:中药神经精神药理学,E-mail:chennh@imm.ac.cn。
