摘要
目的分析青岛地区无偿献血人群梅毒抗体检测结果,为减少抗-TP反应性造成的血液报废、招募低风险无偿献血者、加强用血安全提供参考基础。方法选择青岛地区2017年1月—2022年12月767604例无偿献血者标本,采用2种不同生产厂家酶联免疫吸附实验(enzyme linked immunosorbent assay,ELISA)试剂进行初、复检检测,对各类献血人群梅毒螺旋体抗体(treponema pallidum,TP-Ab)反应性情况进行统计分析。结果共检测767604例,检出反应性1279例,反应率为0.17%。各年度间抗-TP反应率比较,2018年反应率有所偏高,其余5年呈下降趋势,差异有统计学意义(χ^(2)=109.24,P<0.05)。双试剂反应性高于单试剂反应性,双试剂反应率与总反应率比较,差异有统计学意义(χ^(2)=101.97,P<0.05);双试剂反应率与单试剂反应率比较,差异有统计学意义(χ^(2)=98.62,P<0.05)。不同性别反应率比较,女性高于男性,差异有统计学意义(χ^(2)=27.19,P<0.05)。不同民族比较,少数民族高于汉族,差异有统计学意义(χ^(2)=53.70,P<0.05);不同职业比较,个体从业人群高于其他职业人群,差异有统计学意义(χ^(2)=143.97,P<0.05)。不同文化程度比较,初中及以下人群高于其他学历人群,差异有统计学意义(χ^(2)=172.99,P<0.05)。结论实施献血者归队策略,加强对高危人群梅毒性病知识的宣传,做好献血前问询及梅毒快速检测,进一步降低梅毒血液传播风险。
Objective The results of syphilis antibody detection among blood donors in Qingdao were analyzed,to provide a reference basis for reducing blood scrap caused by anti-TP reactivity,recruiting low-risk unpaid blood donors and strengthening blood safety.Methods Samples of 767604 unpaid blood donors from Qingdao area from January 2017 to December 2022 were selected,enzyme-linked immunosorbent assay(ELISA)reagents from two different manufacturers were used for primary and secondary detection,The reactivity of treponema pallidum(TP-Ab)antibody among blood donors was analyzed statistically.Results a total of 767604 people were tested,and 1279 were found to be reactive,the response rate was 0.17%.The anti-TP reaction rate was higher in 2018,and decreased in the other 5 years,the difference was statistically significant(χ^(2)=109.24,P<0.05).Double-reagent reactivity is higher than single-reagent reactivity,the difference between the double reagent reaction rate and the total reaction rate was statistically significant(χ^(2)=101.97,P<0.05),there was significant difference between the reaction rate of two reagents and that of one reagent(χ^(2)=98.62,P<0.05).The response rate of female was higher than that of male(χ^(2)=27.19,P<0.05).Compared with different nationalities,minority nationalities were higher than Han nationality,the difference was statistically significant(χ^(2)=53.70,P<0.05).Compared with other occupations,the self-employed population was higher than that of other occupations,and the difference was statistically significant(χ^(2)=143.97,P<0.05).Compared with different educational levels,the group with junior middle school or below was higher than that with other educational levels,and the difference was statistically significant(χ^(2)=172.99,P<0.05).Conclusion To carry out the strategy of returning blood donors,strengthen the publicity of syphilis venereal disease knowledge among high-risk groups,make inquiries before blood donation and rapid syphilis detection,and further reduce the risk of blood transmission of syphilis.
作者
潘海平
周宝琴
候云
PAN Haiping;ZHOU Baoqin;HOU Yun(Department of Inspection,Qingdao Blood Center,Qingdao Shandong 266071,China)
出处
《中国卫生标准管理》
2023年第10期152-156,共5页
China Health Standard Management
基金
2022年度中国输血协会圣湘输血医学发展基金资助项目(CSBT-SX-2022-03)。
关键词
无偿献血
酶联免疫吸附法
抗-TP检测
反应率
人群分布特征
青岛地区
blood donation without repaymen
enzyme linked immunosorbent assay
anti-TP detection
reaction rate
population distribution characteristics
Qingdao area
