摘要
目的 探讨麻杏石甘汤加减联合西药应用于婴幼儿毛细支气管肺炎治疗的临床疗效。方法 选取2019年1月—2020年10月期间湖南省直中医医院收治的122例毛细支气管肺炎患儿为研究对象,按随机数字表法将患儿分为对照组和治疗组,每组各61例。对照组患儿采用纯西药治疗,治疗组患儿采用中西结合治疗。治疗5~7 d后,观察比较两组患儿临床疗效、临床症状消失时间(啰音消失、退热、喘憋缓解时间)、不良反应发生率及治疗前后血清炎症[肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein, CRP)、白细胞介素-6(Interleukin-6,IL-6)]水平。结果 治疗后治疗组临床总有效率94.55%(52/55)较对照组73.68%(42/57)明显升高,差异有统计学意义(P<0.05)。治疗后治疗组患儿啰音消失、退热、喘憋缓解时间均明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清TNF-α、IL-6、CRP水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血清TNF-α、IL-6、CRP水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率23.64%(12/55)与对照组22.81%(13/57)比较,差异无统计学意义(P>0.05)。结论 麻杏石甘汤加减用于毛细支气管肺炎治疗的药理机制包括:缓解支气管痉挛、抗炎、平喘、镇咳等。麻杏石甘汤全方,法度严谨,配伍巧妙,体现了治病求本以及对立统一的中医治疗思想,其在毛细支气管肺炎的治疗方面有极大的应用价值。
Objective To observe the effect of Maxingshigan Decoction combined with western medicine in the treatment of infants and young children with bronchopneumonia.Methods A total of 122 infants and young children with bronchopneumonia treated in the Hunan Provincial Hospital of Traditional Chinese Medicine from January 2019 to October 2020 were assigned into a control group(n=61)and an observation group(n=61)according to the random number table method.The patients in the control group were treated with western medicine alone,and those in the observation group with modified Maxing Shigan Decoction and western medicine.The treatment in both groups lasted for 5-7 days.The clinical efficacy,the time to disappearance of symptoms(rales,fever,and wheezing),and the incidence of adverse reactions were compared between the two groups.The serum levels of tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)were compared between the two groups and between before and after treatment.Re-sults The observation group had higher total clinical efficacy[94.55%(52/55)vs.73.68%(42/57)]and shorter time to the disappearance of symptoms than the control group(P<0.05).The serum levels of TNF-α,IL-6,and CRP after treatment declined compared with those before treatment,and were lower in the observation group than in the control group(P<0.05).During the treatment period,the incidence of adverse reactions in the observation group(23.64%,12/55)was not significantly different from that(22.81%,13/57)of the control group(P>0.05).Conclusion Modified Maxingsh-igan Decoction can treat bronchopneumonia by relieving bronchospasm,inflammation,asthma,cough and so on.The whole prescription of Maxingshigan Decoction is rigorous in law and ingenious in compatibility.It embodies the traditional Chinese medicine treatment thinking of seeking the root of the disease and the unity of opposites and has great application potential in the treatment of bronchopneumonia.
作者
邱晨
李海霞
张银波
QIU Chen;LI Hai-xia;ZHANG Yin-bo(Hunan Provincial Hospital of Traditional Chinese Medicine,Zhuzhou Hunan 412000;Hunan Children′s Hospital,Changsha Hunan 410007)
出处
《世界中西医结合杂志》
2023年第4期705-709,共5页
World Journal of Integrated Traditional and Western Medicine
基金
湖南省卫生健康委科研项目(20200672)。
关键词
毛细支气管肺炎
麻杏石甘汤
中西医结合
婴幼儿
Bronchopneumonia
Maxingshigan Decoction
Integrated Traditional Chinese and Western Medicine
Infants and Young Children
作者简介
通信作者:李海霞,Email:lihaixia2012@126.com。
